PDB entry 4ly1

View 4ly1 on RCSB PDB site
Description: Structure of Human HDAC2 in complex with inhibitor 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide
Deposited on 2013-07-30, released 2013-08-21
The last revision was dated 2013-10-02, with a file datestamp of 2013-09-27.
Experiment type: XRAY
Resolution: 1.57 Å
R-factor: 0.17
AEROSPACI score: 0.61 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Histone deacetylase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Histone deacetylase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, CA, NA, PG4, 20Y, NHE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4ly1A (A:)
gkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtk
yhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnr
qqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveea
fyttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiis
kvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytir
nvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrl
fenlrmlph

    Sequence, based on observed residues (ATOM records):
    >4ly1A (A:)
gkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtk
yhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnr
qqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveea
fyttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiis
kvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytir
nvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrl
fenlrmlp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4ly1B (B:)
gkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtk
yhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnr
qqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveea
fyttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiis
kvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytir
nvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrl
fenlrmlph

    Sequence, based on observed residues (ATOM records):
    >4ly1B (B:)
kkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtky
hsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnrq
qtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveeaf
yttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiisk
vmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytirn
varcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrlf
enlrmlp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4ly1C (C:)
gkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtk
yhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnr
qqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveea
fyttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiis
kvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytir
nvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrl
fenlrmlph

    Sequence, based on observed residues (ATOM records):
    >4ly1C (C:)
kkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtky
hsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnrq
qtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveeaf
yttdrvmtvsfhkygeyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiisk
vmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytirn
varcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrlf
enlrml