PDB entry 4lvt

View 4lvt on RCSB PDB site
Description: Bcl_2-Navitoclax (ABT-263) Complex
Class: apoptosis regulator/inhibitor
Keywords: 8 helices, APOPTOSIS REGULATOR-INHIBITOR complex
Deposited on 2013-07-26, released 2013-08-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-02, with a file datestamp of 2017-07-28.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415
      • linker (48-49)
    • Uniprot P10415 (50-End)
      • linker (48-49)
    Domains in SCOPe 2.08: d4lvta_
  • Chain 'B':
    Compound: Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415
      • linker (48-49)
    • Uniprot P10415 (50-End)
      • linker (48-49)
    Domains in SCOPe 2.08: d4lvtb_
  • Heterogens: 1XJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lvtA (A:)
mahpgrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqag
ddfsrryrrdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcves
vnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr

    Sequence, based on observed residues (ATOM records): (download) 
    >4lvtA (A:)
ydnreivmkyihyklsqrgyewdasevvhltlrqagddfsrryrrdfaemssqlhltpft
argrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhl
htwiqdnggwdafvelygp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lvtB (B:)
mahpgrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqag
ddfsrryrrdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcves
vnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr

    Sequence, based on observed residues (ATOM records): (download) 
    >4lvtB (B:)
ydnreivmkyihyklsqrgyewdasevvhltlrqagddfsrryrrdfaemssqlhltpft
argrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhl
htwiqdnggwdafvelygp