PDB entry 4lte

View 4lte on RCSB PDB site
Description: Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor
Deposited on 2013-07-23, released 2014-05-21
The last revision was dated 2014-07-23, with a file datestamp of 2014-07-18.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: 0.158
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (68-69)
      • engineered mutation (129)
      • engineered mutation (136)
      • engineered mutation (215)
      • engineered mutation (372)
      • engineered mutation (531)
      • engineered mutation (548)
      • engineered mutation (747)
      • engineered mutation (770)
      • engineered mutation (777)
      • engineered mutation (862)
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (68-69)
      • engineered mutation (129)
      • engineered mutation (136)
      • engineered mutation (215)
      • engineered mutation (372)
      • engineered mutation (531)
      • engineered mutation (548)
      • engineered mutation (747)
      • engineered mutation (770)
      • engineered mutation (777)
      • engineered mutation (862)
  • Chain 'M':
    Compound: Macrocyclic Inhibitor
    Database cross-references and differences (RAF-indexed):
    • PDB 4LTE (Start-4)
  • Chain 'N':
    Compound: Macrocyclic Inhibitor
    Database cross-references and differences (RAF-indexed):
    • PDB 4LTE (Start-4)
  • Heterogens: ZN, EPE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lteA (A:)
mnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdpp
niaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlega
ldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtg
nkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenk
nvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighe
gpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqkl
raegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrp
dliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngk
fklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffsp
fayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpil
lkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelk
ealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllps
qlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafn
tlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteea
fqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyk
emlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrg
lplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >4lteA (A:)
npaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppni
aglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegald
rfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnk
ytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenknv
plpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighegp
gsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklra
egpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpdl
iemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkfk
lptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfa
yvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpillk
kiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelkea
lddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsql
vryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntl
rtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeafq
khiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfykem
lavdaprrhkvsvhvlareminlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lteB (B:)
mnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdpp
niaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlega
ldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtg
nkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenk
nvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighe
gpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqkl
raegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrp
dliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngk
fklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffsp
fayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpil
lkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelk
ealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllps
qlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafn
tlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteea
fqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyk
emlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrg
lplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >4lteB (B:)
npaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppni
aglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegald
rfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnk
ytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenknv
plpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighegp
gsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklra
egpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpdl
iemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkfk
lptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfa
yvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpillk
kiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelkea
lddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsql
vryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntl
rtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeafq
khiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfykem
lavdaprrhkvsvhvlareminlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'M':
    Sequence, based on SEQRES records:
    >4lteM (M:)
qfxkx

    Sequence, based on observed residues (ATOM records):
    >4lteM (M:)
fxkx

  • Chain 'N':
    Sequence, based on SEQRES records:
    >4lteN (N:)
qfxkx

    Sequence, based on observed residues (ATOM records):
    >4lteN (N:)
fxkx