PDB entry 4lsg

View 4lsg on RCSB PDB site
Description: Structure of Mouse P-Glycoprotein
Deposited on 2013-07-22, released 2013-07-31
The last revision was dated 2013-08-07, with a file datestamp of 2013-08-02.
Experiment type: XRAY
Resolution: 3.8 Å
R-factor: 0.338
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Multidrug resistance protein 1a
    Species: Mus musculus [TaxId:10090]
    Gene: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21447
      • engineered mutation (951)
  • Chain 'B':
    Compound: Multidrug resistance protein 1a
    Species: Mus musculus [TaxId:10090]
    Gene: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21447
      • engineered mutation (951)
  • Heterogens: HG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lsgA (A:)
meleedlkgradknfskmgkkskkekkekkpavsvltmfryagwldrlymlvgtlaaiih
gvalplmmlifgdmtdsfasvgnvsknstnmseadkramfakleeemttyayyytgigag
vlivayiqvsfwclaagrqihkirqkffhaimnqeigwfdvhdvgelntrltddvskine
gigdkigmffqamatffggfiigftrgwkltlvilaispvlglsagiwakilssftdkel
hayakagavaeevlaairtviafggqkkelerynnnleeakrlgikkaitanismgaafl
liyasyalafwygtslviskeysigqvltvffsvligafsvgqaspnieafanargaaye
vfkiidnkpsidsfsksghkpdniqgnlefknihfsypsrkevqilkglnlkvksgqtva
lvgnsgcgksttvqlmqrlydpldgmvsidgqdirtinvrylreiigvvsqepvlfatti
aenirygredvtmdeiekavkeanaydfimklphqfdtlvgergaqlsggqkqriaiara
lvrnpkillldeatsaldteseavvqaaldkaregrttiviahrlstvrnadviagfdgg
viveqgnhdelmrekgiyfklvmtqtagneielgneackskdeidnldmsskdsgsslir
rrstrksicgphdqdrklstkealdedvppasfwrilklnstewpyfvvgifcaiinggl
qpafsvifskvvgvftnggppetqrqnsnlfsllflilgiisfitfflqgftfgkageil
tkrlrymvfksmlrqdvswfddpknttgalttrlandaaqvkgatgsrlavifqnianlg
tgiiisliygwqltllllaivpiiaiagvvemkmlsgqalkdkkelegsgkiateaienf
rtvvsltreqkfetmyaqslqipyrnamkkahvfgitfsftqammyfsyaaafrfgaylv
tqqlmtfenvllvfsaivfgamavgqvssfapdyakatvsashiiriiektpeidsystq
glkpnmlegnvqfsgvvfnyptrpsipvlqglslevkkgqtlalvgssgcgkstvvqlle
rfydpmagsvfldgkeikqlnvqwlraqlgivsqepilfdcsiaeniaygdnsrvvsyee
ivraakeanihqfidslpdkyntrvgdkgtqlsggqkqriaiaralvrqphillldeats
aldtesekvvqealdkaregrtciviahrlstiqnadlivviqngkvkehgthqqllaqk
giyfsmvsvqagakrslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >4lsgA (A:)
vsvltmfryagwldrlymlvgtlaaiihgvalplmmlifgdmtdsfasvgnvsknstnms
eadkramfakleeemttyayyytgigagvlivayiqvsfwclaagrqihkirqkffhaim
nqeigwfdvhdvgelntrltddvskinegigdkigmffqamatffggfiigftrgwkltl
vilaispvlglsagiwakilssftdkelhayakagavaeevlaairtviafggqkkeler
ynnnleeakrlgikkaitanismgaaflliyasyalafwygtslviskeysigqvltvff
svligafsvgqaspnieafanargaayevfkiidnkpsidsfsksghkpdniqgnlefkn
ihfsypsrkevqilkglnlkvksgqtvalvgnsgcgksttvqlmqrlydpldgmvsidgq
dirtinvrylreiigvvsqepvlfattiaenirygredvtmdeiekavkeanaydfimkl
phqfdtlvgergaqlsggqkqriaiaralvrnpkillldeatsaldteseavvqaaldka
regrttiviahrlstvrnadviagfdggviveqgnhdelmrekgiyfklvmtqtldedvp
pasfwrilklnstewpyfvvgifcaiingglqpafsvifskvvgvftnggppetqrqnsn
lfsllflilgiisfitfflqgftfgkageiltkrlrymvfksmlrqdvswfddpknttga
lttrlandaaqvkgatgsrlavifqnianlgtgiiisliygwqltllllaivpiiaiagv
vemkmlsgqalkdkkelegsgkiateaienfrtvvsltreqkfetmyaqslqipyrnamk
kahvfgitfsftqammyfsyaaafrfgaylvtqqlmtfenvllvfsaivfgamavgqvss
fapdyakatvsashiiriiektpeidsystqglkpnmlegnvqfsgvvfnyptrpsipvl
qglslevkkgqtlalvgssgcgkstvvqllerfydpmagsvfldgkeikqlnvqwlraql
givsqepilfdcsiaeniaygdnsrvvsyeeivraakeanihqfidslpdkyntrvgdkg
tqlsggqkqriaiaralvrqphillldeatsaldtesekvvqealdkaregrtciviahr
lstiqnadlivviqngkvkehgthqqllaqkgiyfsmvsvqa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lsgB (B:)
meleedlkgradknfskmgkkskkekkekkpavsvltmfryagwldrlymlvgtlaaiih
gvalplmmlifgdmtdsfasvgnvsknstnmseadkramfakleeemttyayyytgigag
vlivayiqvsfwclaagrqihkirqkffhaimnqeigwfdvhdvgelntrltddvskine
gigdkigmffqamatffggfiigftrgwkltlvilaispvlglsagiwakilssftdkel
hayakagavaeevlaairtviafggqkkelerynnnleeakrlgikkaitanismgaafl
liyasyalafwygtslviskeysigqvltvffsvligafsvgqaspnieafanargaaye
vfkiidnkpsidsfsksghkpdniqgnlefknihfsypsrkevqilkglnlkvksgqtva
lvgnsgcgksttvqlmqrlydpldgmvsidgqdirtinvrylreiigvvsqepvlfatti
aenirygredvtmdeiekavkeanaydfimklphqfdtlvgergaqlsggqkqriaiara
lvrnpkillldeatsaldteseavvqaaldkaregrttiviahrlstvrnadviagfdgg
viveqgnhdelmrekgiyfklvmtqtagneielgneackskdeidnldmsskdsgsslir
rrstrksicgphdqdrklstkealdedvppasfwrilklnstewpyfvvgifcaiinggl
qpafsvifskvvgvftnggppetqrqnsnlfsllflilgiisfitfflqgftfgkageil
tkrlrymvfksmlrqdvswfddpknttgalttrlandaaqvkgatgsrlavifqnianlg
tgiiisliygwqltllllaivpiiaiagvvemkmlsgqalkdkkelegsgkiateaienf
rtvvsltreqkfetmyaqslqipyrnamkkahvfgitfsftqammyfsyaaafrfgaylv
tqqlmtfenvllvfsaivfgamavgqvssfapdyakatvsashiiriiektpeidsystq
glkpnmlegnvqfsgvvfnyptrpsipvlqglslevkkgqtlalvgssgcgkstvvqlle
rfydpmagsvfldgkeikqlnvqwlraqlgivsqepilfdcsiaeniaygdnsrvvsyee
ivraakeanihqfidslpdkyntrvgdkgtqlsggqkqriaiaralvrqphillldeats
aldtesekvvqealdkaregrtciviahrlstiqnadlivviqngkvkehgthqqllaqk
giyfsmvsvqagakrslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >4lsgB (B:)
vsvltmfryagwldrlymlvgtlaaiihgvalplmmlifgdmtdsfasvgnvsknstnms
eadkramfakleeemttyayyytgigagvlivayiqvsfwclaagrqihkirqkffhaim
nqeigwfdvhdvgelntrltddvskinegigdkigmffqamatffggfiigftrgwkltl
vilaispvlglsagiwakilssftdkelhayakagavaeevlaairtviafggqkkeler
ynnnleeakrlgikkaitanismgaaflliyasyalafwygtslviskeysigqvltvff
svligafsvgqaspnieafanargaayevfkiidnkpsidsfsksghkpdniqgnlefkn
ihfsypsrkevqilkglnlkvksgqtvalvgnsgcgksttvqlmqrlydpldgmvsidgq
dirtinvrylreiigvvsqepvlfattiaenirygredvtmdeiekavkeanaydfimkl
phqfdtlvgergaqlsggqkqriaiaralvrnpkillldeatsaldteseavvqaaldka
regrttiviahrlstvrnadviagfdggviveqgnhdelmrekgiyfklvmtqtldedvp
pasfwrilklnstewpyfvvgifcaiingglqpafsvifskvvgvftnggppetqrqnsn
lfsllflilgiisfitfflqgftfgkageiltkrlrymvfksmlrqdvswfddpknttga
lttrlandaaqvkgatgsrlavifqnianlgtgiiisliygwqltllllaivpiiaiagv
vemkmlsgqalkdkkelegsgkiateaienfrtvvsltreqkfetmyaqslqipyrnamk
kahvfgitfsftqammyfsyaaafrfgaylvtqqlmtfenvllvfsaivfgamavgqvss
fapdyakatvsashiiriiektpeidsystqglkpnmlegnvqfsgvvfnyptrpsipvl
qglslevkkgqtlalvgssgcgkstvvqllerfydpmagsvfldgkeikqlnvqwlraql
givsqepilfdcsiaeniaygdnsrvvsyeeivraakeanihqfidslpdkyntrvgdkg
tqlsggqkqriaiaralvrqphillldeatsaldtesekvvqealdkaregrtciviahr
lstiqnadlivviqngkvkehgthqqllaqkgiyfsmvsvqa