PDB entry 4lrs

View 4lrs on RCSB PDB site
Description: Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
Class: oxidoreductase
Keywords: Rossmann fold, TIM barrel domain, Dehydrogenase, aldolase, OXIDOREDUCTASE
Deposited on 2013-07-20, released 2013-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-09-04, with a file datestamp of 2013-08-30.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: 0.166
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 4-hydroxy-2-oxovalerate aldolase
    Species: Thermomonospora curvata [TaxId:471852]
    Gene: Tcur_0536
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4lrsa1, d4lrsa2
  • Chain 'B':
    Compound: Acetaldehyde dehydrogenase
    Species: Thermomonospora curvata [TaxId:471852]
    Gene: Tcur_0535
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Symmetric aldolase, C-terminal disordered residues
    Species: Thermomonospora curvata [TaxId:2020]
    Database cross-references and differences (RAF-indexed):
    • PDB 4LRS (0-2)
  • Heterogens: SO4, PYR, CL, MG, GOL, PEG, NAD, FOR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lrsA (A:)
mtdqdgataaprvritdstlrdgshamahqfteeqvratvhaldaagvevievshgdglg
gssfnygfsavdeidlvaaavdeavnakiavlllpgvgtvrdlkrahdagasvariathc
teadvscqhfaaarelgmetvgflmlahrigpeelarqarimvdagaqcvyvvdsagalv
lsdvqarvqalvreigheaqvgfhghqnlslgvansvlayqngarqidgalcalgagagn
spteilaatferlnietgvnvqaalaaaeevvrpylprlpwadraaivqgyagvyssfll
haeraaerygvpaheilqrvgeagyvggqedmiidiavqlaeerhgrpapaggrr

    Sequence, based on observed residues (ATOM records): (download) 
    >4lrsA (A:)
aprvritdstlrdgshamahqfteeqvratvhaldaagvevievshgdglggssfnygfs
avdeidlvaaavdeavnakiavlllpgvgtvrdlkrahdagasvariathcteadvscqh
faaarelgmetvgflmlahrigpeelarqarimvdagaqcvyvvdsagalvlsdvqarvq
alvreigheaqvgfhghqnlslgvansvlayqngarqidgalcalgagagnspteilaat
ferlnietgvnvqaalaaaeevvrpylprlpwadraaivqgyagvyssfllhaeraaery
gvpaheilqrvgeagyvggqedmiidiavqlaeerhg

  • Chain 'B':
    No sequence available.

  • Chain 'N':
    No sequence available.