PDB entry 4lrm

View 4lrm on RCSB PDB site
Description: EGFR D770_N771insNPG in complex with PD168393
Deposited on 2013-07-20, released 2014-01-15
The last revision was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 3.53 Å
R-factor: 0.227
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • insertion (79-81)
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • insertion (79-81)
  • Chain 'C':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (2-End)
      • insertion (79-81)
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • insertion (79-81)
  • Chain 'E':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • insertion (79-81)
  • Heterogens: YUN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lrmA (A:)
gspsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records):
    >4lrmA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsq
yllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhae
ggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekger
lpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsp
tdsnfyr

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lrmB (B:)
gspsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records):
    >4lrmB (B:)
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
ankeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigs
qyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyha
eggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgd

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4lrmC (C:)
gspsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records):
    >4lrmC (C:)
psgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdnig
sqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyh
aeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekg
erlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4lrmD (D:)
gspsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records):
    >4lrmD (D:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsq
yllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhae
ggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekger
lpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylvi

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4lrmE (E:)
gspsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records):
    >4lrmE (E:)
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnpgnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqg