PDB entry 4lrh

View 4lrh on RCSB PDB site
Description: crystal structure of human folate receptor alpha in complex with folic acid
Deposited on 2013-07-19, released 2013-07-31
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15328 (Start-212)
      • expression tag (213)
  • Chain 'B':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15328 (Start-212)
      • expression tag (213-215)
  • Chain 'D':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15328 (Start-212)
      • expression tag (213-214)
  • Chain 'G':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Folate receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLR1, FOLR
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FOL, NAG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lrhA (A:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhA (A:)
rtellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnhc
gemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrts
ytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgrc
iqmwfdpaqgnpneevarfyaaamsgt

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lrhB (B:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhB (B:)
tellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnhcg
emapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrtsy
tcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgrci
qmwfdpaqgnpneevarfyaaams

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4lrhC (C:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhC (C:)
rtellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnhc
gemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrts
ytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgrc
iqmwfdpaqgnpneevarfyaaamsgtlv

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4lrhD (D:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhD (D:)
iawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfn
wnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwed
crtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrg
sgrciqmwfdpaqgnpneevarfyaaamsg

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4lrhE (E:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhE (E:)
artellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnh
cgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrt
sytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgr
ciqmwfdpaqgnpneevarfyaaams

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4lrhF (F:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhF (F:)
rtellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnhc
gemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrts
ytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgrc
iqmwfdpaqgnpneevarfyaaamsgtl

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4lrhG (G:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhG (G:)
rtellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnhc
gemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrts
ytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgrc
iqmwfdpaqgnpneevarfyaaams

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4lrhH (H:)
qtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsyly
rfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqw
wedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsny
srgsgrciqmwfdpaqgnpneevarfyaaamsgtlvpr

    Sequence, based on observed residues (ATOM records):
    >4lrhH (H:)
rtellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnhc
gemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrts
ytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgrc
iqmwfdpaqgnpneevarfyaaam