PDB entry 4lqm

View 4lqm on RCSB PDB site
Description: EGFR L858R in complex with PD168393
Class: transferase/transferase inhibitor
Keywords: EGFR, Kinase, PD168393, 34-jab, transferase-transferase inhibitor complex
Deposited on 2013-07-19, released 2014-01-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.187
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (166)
    Domains in SCOPe 2.08: d4lqma_
  • Heterogens: DJK, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lqmA (A:)
gspsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigs
qyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyha
eggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlps
ptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >4lqmA (A:)
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikeltspkankei
ldeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeegkvpikwmalesi
lhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymi
mvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsalmdeedmddvvdad
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