PDB entry 4lop

View 4lop on RCSB PDB site
Description: Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)
Deposited on 2013-07-13, released 2013-08-21
The last revision was dated 2013-10-23, with a file datestamp of 2013-10-18.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.15
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 14
    Species: Mus musculus [TaxId:10090]
    Gene: Mapk14, Crk1, Csbp1, Csbp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 14
    Species: Mus musculus [TaxId:10090]
    Gene: Mapk14, Crk1, Csbp1, Csbp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Mitogen-activated protein kinase 14
    Species: Mus musculus [TaxId:10090]
    Gene: Mapk14, Crk1, Csbp1, Csbp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Mitogen-activated protein kinase 14
    Species: Mus musculus [TaxId:10090]
    Gene: Mapk14, Crk1, Csbp1, Csbp2
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: tgf-beta-activated kinase 1 and map3k7-binding protein 1
    Species: MUS MUSCULUS, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: tgf-beta-activated kinase 1 and map3k7-binding protein 1
    Species: MUS MUSCULUS, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: tgf-beta-activated kinase 1 and map3k7-binding protein 1
    Species: MUS MUSCULUS, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: tgf-beta-activated kinase 1 and map3k7-binding protein 1
    Species: MUS MUSCULUS, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SB4, TLA, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lopA (A:)
gmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpf
qsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkc
qkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddem
tgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlv
gtpgaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkrita
aqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeeme
s

    Sequence, based on observed residues (ATOM records):
    >4lopA (A:)
qerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsi
ihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkl
tddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgy
vatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtp
gaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqa
lahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lopB (B:)
gmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpf
qsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkc
qkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddem
tgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlv
gtpgaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkrita
aqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeeme
s

    Sequence, based on observed residues (ATOM records):
    >4lopB (B:)
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyv
atrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpg
aellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqal
ahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4lopC (C:)
gmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpf
qsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkc
qkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddem
tgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlv
gtpgaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkrita
aqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeeme
s

    Sequence, based on observed residues (ATOM records):
    >4lopC (C:)
qerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsi
ihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkl
tddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgy
vatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtp
gaelnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyh
dpddepvadpydqsfesrdllidewksltydevisfvpppl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4lopD (D:)
gmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpf
qsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkc
qkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddem
tgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlv
gtpgaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkrita
aqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeeme
s

    Sequence, based on observed residues (ATOM records):
    >4lopD (D:)
qerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsi
ihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkl
tddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgy
vatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtp
gaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqa
lahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

  • Chain 'K':
    Sequence, based on SEQRES records:
    >4lopK (K:)
rvypvsvpyssaqstsktsvtlslvmpsq

    Sequence, based on observed residues (ATOM records):
    >4lopK (K:)
rvypvsvpyssatlslvmpsq

  • Chain 'L':
    Sequence, based on SEQRES records:
    >4lopL (L:)
rvypvsvpyssaqstsktsvtlslvmpsq

    Sequence, based on observed residues (ATOM records):
    >4lopL (L:)
rvypvsvpyssatlslvmpsq

  • Chain 'M':
    Sequence, based on SEQRES records:
    >4lopM (M:)
rvypvsvpyssaqstsktsvtlslvmpsq

    Sequence, based on observed residues (ATOM records):
    >4lopM (M:)
vypvsvpysstlslvmps

  • Chain 'N':
    Sequence, based on SEQRES records:
    >4lopN (N:)
rvypvsvpyssaqstsktsvtlslvmpsq

    Sequence, based on observed residues (ATOM records):
    >4lopN (N:)
rvypvsvpysstlslvmps