PDB entry 4lof

View 4lof on RCSB PDB site
Description: Human p53 Core Domain Mutant V157F/N235K/N239Y
Class: apoptosis
Keywords: Beta Sandwich, Tumor Suppressor, DNA Binding, Nuclear, Apoptosis
Deposited on 2013-07-12, released 2013-07-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-17, with a file datestamp of 2019-07-12.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (0-End)
      • engineered mutation (63)
      • engineered mutation (141)
      • engineered mutation (145)
    Domains in SCOPe 2.08: d4lofa_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lofA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihykymcysscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4lofA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihykymcysscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrk