PDB entry 4lng

View 4lng on RCSB PDB site
Description: Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Class: transferase
Keywords: Farnesyltransferase, Prenylation, Isoprenoid and CAAX-containing protein and peptide substrates, Farnesylation, transferase
Deposited on 2013-07-11, released 2014-01-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-26, with a file datestamp of 2014-03-21.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: 0.156
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: CaaX farnesyltransferase alpha subunit Ram2
    Species: Aspergillus fumigatus [TaxId:330879]
    Gene: AFUA_4G07800, NCBI Locus XM_746952 Ram2 gene
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4WP27
      • engineered mutation (159)
    Domains in SCOPe 2.08: d4lnga_
  • Chain 'B':
    Compound: CaaX farnesyltransferase beta subunit Ram1
    Species: Aspergillus fumigatus [TaxId:330879]
    Gene: AFUA_4G10330, NCBI Locus XM_746700 Ram1 gene
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EDO, ZN, JAN, FPP, K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lngA (A:)
mgsshhhhhhsqdpmegkyssdpewasikpielndgsdfgamplatisyspeyleatsyl
ravmaanemseralrltgdiismnpahytvwiyrakilfalgkdlneeiewlnkvalkhl
knyqiwhhrqvlmssrahfptlppreqdflmemfaqdaksyhvwtyrhwlvrhfklwdhp
reiqdveallkadvrnnsawnhrymlrfgprdenefdaglhnttgpssekgrlpvvdedl
vdselqysqsrileapenrspwsyargvlqaagrplsewkdfarsfvvekqengqvvdva
vksshaiewladvyaeedgsegsaaeavkmltllkekydpirrnyweyrirqitasaaha
teisasa

    Sequence, based on observed residues (ATOM records): (download) 
    >4lngA (A:)
gkyssdpewasikpielndgsdfgamplatisyspeyleatsylravmaanemseralrl
tgdiismnpahytvwiyrakilfalgkdlneeiewlnkvalkhlknyqiwhhrqvlmssr
ahfptlppreqdflmemfaqdaksyhvwtyrhwlvrhfklwdhpreiqdveallkadvrn
nsawnhrymlrfgprdenefdaglhnttgpssekgrlpvvdedlvdselqysqsrileap
enrspwsyargvlqaagrplsewkdfarsfvavksshaiewladvyaeedgsegsaaeav
kmltllkekydpirrnyweyrirqitasaahatei

  • Chain 'B':
    No sequence available.