PDB entry 4lmu

View 4lmu on RCSB PDB site
Description: Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002)
Class: transferase/transferase inhibitor
Keywords: co-crystallization, SKF86002, fluorescence, inhibitor screening, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-07-11, released 2014-02-12
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-02-12, with a file datestamp of 2014-02-07.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: 0.172
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4lmua_
  • Heterogens: QUE, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4lmuA (A:)
    mkekeplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvp
    mevvllkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsf
    fwqvleavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvy
    sppewiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhli
    rwclalrpsdrptfeeiqnhpwmqdvllpqetaeihlhslspgpsksgpssgenlyfq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4lmuA (A:)
    sqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgetrvpmevvllkkvssg
    fsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhch
    ncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhryh
    grsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrp
    tfeeiqnhpwmqdvllpqetaeihl