PDB entry 4lmu

View 4lmu on RCSB PDB site
Description: Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002)
Class: transferase/transferase inhibitor
Keywords: co-crystallization, SKF86002, fluorescence, inhibitor screening, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-07-11, released 2014-02-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4lmua_
  • Heterogens: QUE, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lmuA (A:)
mkekeplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvp
mevvllkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsf
fwqvleavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvy
sppewiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhli
rwclalrpsdrptfeeiqnhpwmqdvllpqetaeihlhslspgpsksgpssgenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >4lmuA (A:)
sqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgetrvpmevvllkkvssg
fsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhch
ncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhryh
grsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrp
tfeeiqnhpwmqdvllpqetaeihl