PDB entry 4lkc

View 4lkc on RCSB PDB site
Description: An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo
Class: immune system
Keywords: Immunoglobulin, Antibody, PCSK9, IMMUNE SYSTEM
Deposited on 2013-07-07, released 2013-08-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-12, with a file datestamp of 2014-02-07.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.175
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab fragment of PCSK9 antibody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4LKC (0-End)
    Domains in SCOPe 2.08: d4lkca1, d4lkca2
  • Chain 'B':
    Compound: Fab fragment of PCSK9 antibody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4LKC (0-End)
    Domains in SCOPe 2.08: d4lkcb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lkcA (A:)
aiqltqspsslsasvgdrvtitcrasqgissalawyqqkpgkapklliydasslesgvps
rfsgsgsgtdftltisslqpedfatyycqqfnsylitfgqgtrleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4lkcA (A:)
aiqltqspsslsasvgdrvtitcrasqgissalawyqqkpgkapklliydasslesgvps
rfsgsgsgtdftltisslqpedfatyycqqfnsylitfgqgtrleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lkcB (B:)
evqlvesggglvqpggslrlscaasgftfssydmhwvrqatgkglewvsaigtagdtyyp
dsvkgrftisrenaknslylqmnslragdtavyycvregtyyhdsgsdnyysygmdvwgq
gttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >4lkcB (B:)
evqlvesggglvqpggslrlscaasgftfssydmhwvrqatgkglewvsaigtagdtyyp
dsvkgrftisrenaknslylqmnslragdtavyycvregtyyhdsgsdnyysygmdvwgq
gttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps