PDB entry 4lh4

View 4lh4 on RCSB PDB site
Description: Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
Class: transferase
Keywords: integrase, TRANSFERASE
Deposited on 2013-06-30, released 2013-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-12-25, with a file datestamp of 2013-12-20.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.202
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WJM2
      • natural variant (82)
      • engineered mutation (154)
    Domains in SCOPe 2.08: d4lh4a_
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lh4A (A:)
mgsshhhhhhssglvprgsmhgqvdcspgiwqldcthlegkvilvavhvasgyieaevip
aetgqetayfllklagrwpvktvhtdngsnftsttvkaacwwagikqefgipynpqsqgv
vesmnkelkkiigqvrdqaehlktavqmavfihnkkrkggiggysagerivdiiatdiqt
ke

    Sequence, based on observed residues (ATOM records): (download) 
    >4lh4A (A:)
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsttvkaacwwagikqmnkelkkiigqvrdqaehlktavqmavfihnkkrkysag
erivdiiatdi