PDB entry 4lh1

View 4lh1 on RCSB PDB site
Description: Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with malonate
Class: oxidoreductase
Keywords: Proline catabolism Substrate recognition, Rossmann Fold, OXIDOREDUCTASE
Deposited on 2013-06-30, released 2013-08-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-04-29, with a file datestamp of 2015-04-24.
Experiment type: XRAY
Resolution: 1.67 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Species: Mus musculus [TaxId:10090]
    Gene: Aldh4a1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8CHT0 (Start-562)
      • conflict (32)
      • conflict (60)
      • conflict (467)
    Domains in SCOPe 2.08: d4lh1a_
  • Chain 'B':
    Compound: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Species: Mus musculus [TaxId:10090]
    Gene: Aldh4a1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8CHT0 (21-562)
      • expression tag (18-20)
      • conflict (32)
      • conflict (60)
      • conflict (467)
    Domains in SCOPe 2.08: d4lh1b1, d4lh1b2
  • Heterogens: MLA, 1PE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lh1A (A:)
mgsshhhhhhssglvprgshmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgq
teaipcvvgdeevwtsdiqyqlspfnhahkvakfcyadkallnraidaalaarkewdlkp
madraqvflkaadmlsgprraevlaktmvgqgktviqaeidaaaelidffrfnakfavel
egeqpisvppstnhtvyrglegfvaaispfnftaiggnlagapalmgnvvlwkpsdtaml
asyavyrilreaglppniiqfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaq
nldrfrtfprlagecggknfhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpksl
wpqikgrlleehsrikvgdpaedfgtffsavidakafarikkwleharsspslsilaggq
cnesvgyyvepciieskdpqepimkeeifgpvltvyvypddkyretlklvdsttsygltg
avfaqdkaivqeatrmlrnaagnfyindkstgsvvgqqpfggarasgtndkpggphyilr
wtspqvikethkplgdwrysymq

    Sequence, based on observed residues (ATOM records): (download) 
    >4lh1A (A:)
lkvanepilafsqgsperdalqkalkdlkgqteaipcvvgdeevwtsdiqyqlspfnhah
kvakfcyadkallnraidaalaarkewdlkpmadraqvflkaadmlsgprraevlaktmv
gqgktviqaeidaaaelidffrfnakfavelegeqpisvppstnhtvyrglegfvaaisp
fnftaiggnlagapalmgnvvlwkpsdtamlasyavyrilreaglppniiqfvpadgptf
gdtvtssehlcginftgsvptfkhlwrqvaqnldrfrtfprlagecggknfhfvhssadv
dsvvsgtlrsafeyggqkcsacsrlyvpkslwpqikgrlleehsrikvgdpaedfgtffs
avidakafarikkwleharsspslsilaggqcnesvgyyvepciieskdpqepimkeeif
gpvltvyvypddkyretlklvdsttsygltgavfaqdkaivqeatrmlrnaagnfyindk
stgsvvgqqpfggarasgtndkpggphyilrwtspqvikethkplgdwrysymq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lh1B (B:)
mgsshhhhhhssglvprgshmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgq
teaipcvvgdeevwtsdiqyqlspfnhahkvakfcyadkallnraidaalaarkewdlkp
madraqvflkaadmlsgprraevlaktmvgqgktviqaeidaaaelidffrfnakfavel
egeqpisvppstnhtvyrglegfvaaispfnftaiggnlagapalmgnvvlwkpsdtaml
asyavyrilreaglppniiqfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaq
nldrfrtfprlagecggknfhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpksl
wpqikgrlleehsrikvgdpaedfgtffsavidakafarikkwleharsspslsilaggq
cnesvgyyvepciieskdpqepimkeeifgpvltvyvypddkyretlklvdsttsygltg
avfaqdkaivqeatrmlrnaagnfyindkstgsvvgqqpfggarasgtndkpggphyilr
wtspqvikethkplgdwrysymq

    Sequence, based on observed residues (ATOM records): (download) 
    >4lh1B (B:)
shmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgqteaipcvvgdeevwtsdi
qyqlspfnhahkvakfcyadkallnraidaalaarkewdlkpmadraqvflkaadmlsgp
rraevlaktmvgqgktviqaeidaaaelidffrfnakfavelegeqpisvppstnhtvyr
glegfvaaispfnftaiggnlagapalmgnvvlwkpsdtamlasyavyrilreaglppni
iqfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaqnldrfrtfprlagecggk
nfhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpkslwpqikgrlleehsrikvg
dpaedfgtffsavidakafarikkwleharsspslsilaggqcnesvgyyvepciieskd
pqepimkeeifgpvltvyvypddkyretlklvdsttsygltgavfaqdkaivqeatrmlr
naagnfyindkstgsvvgqqpfggarasgtndkpggphyilrwtspqvikethkplgdwr
ysymq