PDB entry 4lgd

View 4lgd on RCSB PDB site
Description: structural basis for autoactivation of human mst2 kinase and its regulation by rassf5
Deposited on 2013-06-27, released 2013-09-18
The last revision was dated 2018-02-28, with a file datestamp of 2018-02-23.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188 (Start-313)
      • engineered mutation (146)
    • Uniprot Q13188
  • Chain 'B':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188 (Start-313)
      • engineered mutation (146)
    • Uniprot Q13188
  • Chain 'C':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188 (Start-313)
      • engineered mutation (146)
    • Uniprot Q13188
  • Chain 'D':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188 (Start-313)
      • engineered mutation (146)
    • Uniprot Q13188
  • Chain 'E':
    Compound: Ras association domain family member 5, RASSF5
    Species: Homo sapiens [TaxId:9606]
    Gene: Rassf5, Nore1, Rapl
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Ras association domain family member 5, RASSF5
    Species: Homo sapiens [TaxId:9606]
    Gene: Rassf5, Nore1, Rapl
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Ras association domain family member 5, RASSF5
    Species: Homo sapiens [TaxId:9606]
    Gene: Rassf5, Nore1, Rapl
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Ras association domain family member 5, RASSF5
    Species: Homo sapiens [TaxId:9606]
    Gene: Rassf5, Nore1, Rapl
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ANP, MG, SO4, NA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lgdA (A:)
mhhhhhhgssklkklsedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvp
vesdlqeiikeisimqqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktli
edeiatilkstlkgleylhfmrkihrnikagnillnteghakladfgvagqltdtmakrn
tvigtpfwmapeviqeigyncvadiwslgitsiemaegkppyadihpmraifmiptnppp
tfrkpelwsddftdfvkkclvknpeqratatqllqhpfiknakpvsilrdliteameika
krheeqqreleeeenwkvpqdgdfdflknlsleelqmrlkaldpmmereieelrqrytak
rqpildamdakkrrqqnf

    Sequence, based on observed residues (ATOM records):
    >4lgdA (A:)
edsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisimq
qcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgle
ylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviqe
igyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdfv
kkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeeefd
flknlsleelqmrlkaldpmmereieelrqrytakrqpildamdakkrrq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lgdB (B:)
mhhhhhhgssklkklsedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvp
vesdlqeiikeisimqqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktli
edeiatilkstlkgleylhfmrkihrnikagnillnteghakladfgvagqltdtmakrn
tvigtpfwmapeviqeigyncvadiwslgitsiemaegkppyadihpmraifmiptnppp
tfrkpelwsddftdfvkkclvknpeqratatqllqhpfiknakpvsilrdliteameika
krheeqqreleeeenwkvpqdgdfdflknlsleelqmrlkaldpmmereieelrqrytak
rqpildamdakkrrqqnf

    Sequence, based on observed residues (ATOM records):
    >4lgdB (B:)
klkklsedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiik
eisimqqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilks
tlkgleylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwma
peviqeigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsd
dftdfvkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqrel
eeeelsleelqmrlkaldpmmereieelrqrytakrqpildamdakkrrq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4lgdC (C:)
mhhhhhhgssklkklsedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvp
vesdlqeiikeisimqqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktli
edeiatilkstlkgleylhfmrkihrnikagnillnteghakladfgvagqltdtmakrn
tvigtpfwmapeviqeigyncvadiwslgitsiemaegkppyadihpmraifmiptnppp
tfrkpelwsddftdfvkkclvknpeqratatqllqhpfiknakpvsilrdliteameika
krheeqqreleeeenwkvpqdgdfdflknlsleelqmrlkaldpmmereieelrqrytak
rqpildamdakkrrqqnf

    Sequence, based on observed residues (ATOM records):
    >4lgdC (C:)
kklsedsltkqpeevfdvleksvfkaihkesgqvvaikqvpvesdlqeiikeisimqqcd
spyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgleylh
fmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviqeigy
ncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdfvkkc
lvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeeefdflk
nlsleelqmrlkaldpmmereieelrqrytakrqpildamdakkrrqqn

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4lgdD (D:)
mhhhhhhgssklkklsedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvp
vesdlqeiikeisimqqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktli
edeiatilkstlkgleylhfmrkihrnikagnillnteghakladfgvagqltdtmakrn
tvigtpfwmapeviqeigyncvadiwslgitsiemaegkppyadihpmraifmiptnppp
tfrkpelwsddftdfvkkclvknpeqratatqllqhpfiknakpvsilrdliteameika
krheeqqreleeeenwkvpqdgdfdflknlsleelqmrlkaldpmmereieelrqrytak
rqpildamdakkrrqqnf

    Sequence, based on observed residues (ATOM records):
    >4lgdD (D:)
lkklsedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiike
isimqqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkst
lkgleylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmap
eviqeigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsdd
ftdfvkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqrele
eeeldpmmereieelrqrytakrqpildamdakkrrqq

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4lgdE (E:)
gevewdafsipelqnfltilekeeqdkiqqvqkkydkfrqkleealres

    Sequence, based on observed residues (ATOM records):
    >4lgdE (E:)
vewdafsipelqnfltilekeeqdkiqqvqkkydkfrqkleealres

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4lgdF (F:)
gevewdafsipelqnfltilekeeqdkiqqvqkkydkfrqkleealres

    Sequence, based on observed residues (ATOM records):
    >4lgdF (F:)
dafsipelqnfltilekeeqdkiqqvqkk

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4lgdG (G:)
gevewdafsipelqnfltilekeeqdkiqqvqkkydkfrqkleealres

    Sequence, based on observed residues (ATOM records):
    >4lgdG (G:)
evewdafsipelqnfltilekeeqdkiqqvqkkydkfrqkleealres

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4lgdH (H:)
gevewdafsipelqnfltilekeeqdkiqqvqkkydkfrqkleealres

    Sequence, based on observed residues (ATOM records):
    >4lgdH (H:)
evewdafsipelqnfltilekeeqdkiqqvqkkydkfrqk