PDB entry 4ldo

View 4ldo on RCSB PDB site
Description: structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody
Deposited on 2013-06-24, released 2013-09-25
The last revision was dated 2017-08-09, with a file datestamp of 2017-08-04.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysozyme, Beta-2 adrenergic receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00720 (15-174)
      • expression tag (6-14)
      • engineered mutation (67)
      • engineered mutation (110)
      • linker (175-176)
    • Uniprot P07550 (177-383)
      • engineered mutation (244)
      • engineered mutation (246)
      • engineered mutation (335)
    • Uniprot P07550 (384-End)
      • engineered mutation (385)
  • Chain 'B':
    Compound: Camelid Antibody Fragment
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4LDO (0-119)
  • Heterogens: 1WV, ALE, NA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4ldoA (A:)
dykddddaenlyfqgnifemlrideglrlkiykdtegyytigighlltkspslnaaksel
dkaigrntngvitkdeaeklfnqdvdaavrgilrnaklkpvydsldavrraalinmvfqm
getgvagftnslrmlqqkrwdeaavnlaksrwynqtpnrakrvittfrtgtwdayaadev
wvvgmgivmslivlaivfgnvlvitaiakferlqtvtnyfitslacadlvmglavvpfga
ahiltktwtfgnfwcefwtsidvlcvtasietlcviavdryfaitspfkyqslltknkar
viilmvwivsgltsflpiqmhwyrathqeaincyaeetccdfftnqayaiassivsfyvp
lvimvfvysrvfqeakrqlqkidkfalkehkalktlgiimgtftlcwlpffivnivhviq
dnlirkevyillnwigyvnsgfnpliycrspdfriafqellclrrsslk

    Sequence, based on observed residues (ATOM records):
    >4ldoA (A:)
daenlyfqgnifemlrideglrlkiykdtegyytigighlltkspslnaakseldkaigr
ntngvitkdeaeklfnqdvdaavrgilrnaklkpvydsldavrraalinmvfqmgetgva
gftnslrmlqqkrwdeaavnlaksrwynqtpnrakrvittfrtgtwdayaadevwvvgmg
ivmslivlaivfgnvlvitaiakferlqtvtnyfitslacadlvmglavvpfgaahiltk
twtfgnfwcefwtsidvlcvtasietlcviavdryfaitspfkyqslltknkarviilmv
wivsgltsflpiqmhwyrathqeaincyaeetccdfftnqayaiassivsfyvplvimvf
vysrvfqeakrqlqkfalkehkalktlgiimgtftlcwlpffivnivhviqdnlirkevy
illnwigyvnsgfnpliycrspdfriafqellcl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >4ldoB (B:)
qvqlqesggglvqaggslrlscaasgsifalnimgwyrqapgkqrelvaaihsggttnya
nsvkgrftisrdnaantvylqmnslkpedtavyycnvkdfgaiiydydywgqgtqvtvss