PDB entry 4lcw

View 4lcw on RCSB PDB site
Description: The structure of human MAIT TCR in complex with MR1-K43A-RL-6-Me-7OH
Class: Membrane Protein/Immune System
Keywords: MHC Class I-related protein, MAIT T cell receptor, Vitamin B2 metabolites, Membrane Protein-Immune System complex
Deposited on 2013-06-24, released 2013-10-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-11-20, with a file datestamp of 2013-11-15.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.181
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-End)
      • expression tag (0)
      • engineered mutation (43)
      • engineered mutation (261)
    Domains in SCOPe 2.06: d4lcwa1, d4lcwa2, d4lcwa3
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4lcwb_
  • Chain 'C':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-End)
      • expression tag (0)
      • engineered mutation (43)
      • engineered mutation (261)
    Domains in SCOPe 2.06: d4lcwc1, d4lcwc2, d4lcwc3
  • Chain 'D':
    Compound: MAIT T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR alpha
    Database cross-references and differences (RAF-indexed):
    • PDB 4LCW (0-End)
    Domains in SCOPe 2.06: d4lcwd1, d4lcwd2
  • Chain 'E':
    Compound: MAIT T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR beta
    Database cross-references and differences (RAF-indexed):
    • PDB 4LCW
    Domains in SCOPe 2.06: d4lcwe1, d4lcwe2
  • Chain 'F':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4lcwf_
  • Chain 'G':
    Compound: MAIT T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR alpha
    Database cross-references and differences (RAF-indexed):
    • PDB 4LCW (0-End)
    Domains in SCOPe 2.06: d4lcwg1, d4lcwg2
  • Chain 'H':
    Compound: MAIT T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR beta
    Database cross-references and differences (RAF-indexed):
    • PDB 4LCW
    Domains in SCOPe 2.06: d4lcwh1, d4lcwh2
  • Heterogens: GOL, 1VY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lcwA (A:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqaeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasieldpqssnlyschvehsgvhmvlqvp

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwA (A:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqaeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasiellyschvehsgvhmvlqv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lcwB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4lcwC (C:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqaeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasieldpqssnlyschvehsgvhmvlqvp

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwC (C:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqaeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrktalfckahgfyppeiymtwmkngeeidygdilpsgdgtyqawasielsnl
yschvehsgvhmvlqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4lcwD (D:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwD (D:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpsp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4lcwE (E:)
nagvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgev
pngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlkn
vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
wgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwE (E:)
agvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgevp
ngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gra

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4lcwF (F:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwF (F:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4lcwG (G:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwG (G:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrsvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnfacanafnnsi
ipedtffp

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4lcwH (H:)
nagvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgev
pngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlkn
vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
wgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >4lcwH (H:)
gvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgevpn
gynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlknvf
ppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqp
alndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg