PDB entry 4lcm

View 4lcm on RCSB PDB site
Description: simvastatin synthase (lovd), from aspergillus terreus, lovd9 mutant (simh9014)
Deposited on 2013-06-21, released 2014-04-02
The last revision was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 3.19 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (Start-414)
      • engineered mutation (27)
      • engineered mutation (29)
      • engineered mutation (36)
      • engineered mutation (41)
      • engineered mutation (44)
      • engineered mutation (61)
      • engineered mutation (97)
      • engineered mutation (110)
      • engineered mutation (124)
      • engineered mutation (158)
      • engineered mutation (165)
      • engineered mutation (173)
      • engineered mutation (175)
      • engineered mutation (179)
      • engineered mutation (192-193)
      • engineered mutation (242)
      • engineered mutation (248)
      • engineered mutation (251)
      • engineered mutation (257)
      • engineered mutation (276)
      • engineered mutation (298)
      • engineered mutation (336)
      • engineered mutation (362)
      • engineered mutation (371)
      • engineered mutation (384)
      • engineered mutation (392)
      • engineered mutation (405)
  • Chain 'B':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (Start-414)
      • engineered mutation (27)
      • engineered mutation (29)
      • engineered mutation (36)
      • engineered mutation (41)
      • engineered mutation (44)
      • engineered mutation (61)
      • engineered mutation (97)
      • engineered mutation (110)
      • engineered mutation (124)
      • engineered mutation (158)
      • engineered mutation (165)
      • engineered mutation (173)
      • engineered mutation (175)
      • engineered mutation (179)
      • engineered mutation (192-193)
      • engineered mutation (242)
      • engineered mutation (248)
      • engineered mutation (251)
      • engineered mutation (257)
      • engineered mutation (276)
      • engineered mutation (298)
      • engineered mutation (336)
      • engineered mutation (362)
      • engineered mutation (371)
      • engineered mutation (384)
      • engineered mutation (392)
      • engineered mutation (405)
  • Chain 'C':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (Start-414)
      • engineered mutation (27)
      • engineered mutation (29)
      • engineered mutation (36)
      • engineered mutation (41)
      • engineered mutation (44)
      • engineered mutation (61)
      • engineered mutation (97)
      • engineered mutation (110)
      • engineered mutation (124)
      • engineered mutation (158)
      • engineered mutation (165)
      • engineered mutation (173)
      • engineered mutation (175)
      • engineered mutation (179)
      • engineered mutation (192-193)
      • engineered mutation (242)
      • engineered mutation (248)
      • engineered mutation (251)
      • engineered mutation (257)
      • engineered mutation (276)
      • engineered mutation (298)
      • engineered mutation (336)
      • engineered mutation (362)
      • engineered mutation (371)
      • engineered mutation (384)
      • engineered mutation (392)
      • engineered mutation (405)
  • Chain 'D':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (Start-414)
      • engineered mutation (27)
      • engineered mutation (29)
      • engineered mutation (36)
      • engineered mutation (41)
      • engineered mutation (44)
      • engineered mutation (61)
      • engineered mutation (97)
      • engineered mutation (110)
      • engineered mutation (124)
      • engineered mutation (158)
      • engineered mutation (165)
      • engineered mutation (173)
      • engineered mutation (175)
      • engineered mutation (179)
      • engineered mutation (192-193)
      • engineered mutation (242)
      • engineered mutation (248)
      • engineered mutation (251)
      • engineered mutation (257)
      • engineered mutation (276)
      • engineered mutation (298)
      • engineered mutation (336)
      • engineered mutation (362)
      • engineered mutation (371)
      • engineered mutation (384)
      • engineered mutation (392)
      • engineered mutation (405)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lcmA (A:)
mvmgsnidaavaadpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrd
ennqlpplqvdtpcrlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfd
dagnprlrerrgkitlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfappl
vndpgaewiygagidwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarr
admthrnssdgklryddtvyfrhdgeecfggqgvfsspgsymkvlhsllkrdglllqpgt
vdlmfqpaleprleeqmnqhmdasphinyggpmpmvmrrsfglggiialedldgenwrrk
gsmtfgggpniiwqidpkaglctlvffqlepwsdpvcrdltrtfekaiyaqyqqghhhhh
h

    Sequence, based on observed residues (ATOM records):
    >4lcmA (A:)
dpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrdennqlpplqvdtp
crlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfddagnprlrerrgk
itlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfapplvndpgaewiygag
idwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradmthrnssdgkl
ryddtcfggqgvfsspgsymkvlhsllkrdglllqpgtvdlmfqpaleprleeqmnqhmd
asphinyggpmpmvmrrsfglggiialedldgenwrrkgsmtfgggpniiwqidpkaglc
tlvffqlepwsdpvcrdltrtfekaiyaqyqqg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lcmB (B:)
mvmgsnidaavaadpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrd
ennqlpplqvdtpcrlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfd
dagnprlrerrgkitlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfappl
vndpgaewiygagidwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarr
admthrnssdgklryddtvyfrhdgeecfggqgvfsspgsymkvlhsllkrdglllqpgt
vdlmfqpaleprleeqmnqhmdasphinyggpmpmvmrrsfglggiialedldgenwrrk
gsmtfgggpniiwqidpkaglctlvffqlepwsdpvcrdltrtfekaiyaqyqqghhhhh
h

    Sequence, based on observed residues (ATOM records):
    >4lcmB (B:)
dpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrdennqlpplqvdtp
crlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfddagnprlrerrgk
itlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfapplvndpgaewiygag
idwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradmthrnssdgkl
ryddtcfggqgvfsspgsymkvlhsllkrdglllqpgtvdlmfqpaleprleeqmnqhmd
asphinyggpmpmvmrrsfglggiialedldgenwrrkgsmtfgggpniiwqidpkaglc
tlvffqlepwsdpvcrdltrtfekaiyaqyqqg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4lcmC (C:)
mvmgsnidaavaadpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrd
ennqlpplqvdtpcrlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfd
dagnprlrerrgkitlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfappl
vndpgaewiygagidwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarr
admthrnssdgklryddtvyfrhdgeecfggqgvfsspgsymkvlhsllkrdglllqpgt
vdlmfqpaleprleeqmnqhmdasphinyggpmpmvmrrsfglggiialedldgenwrrk
gsmtfgggpniiwqidpkaglctlvffqlepwsdpvcrdltrtfekaiyaqyqqghhhhh
h

    Sequence, based on observed residues (ATOM records):
    >4lcmC (C:)
dpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrdennqlpplqvdtp
crlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfddagnprlrerrgk
itlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfapplvndpgaewiygag
idwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradmthrnssdgkl
ryddtcfggqgvfsspgsymkvlhsllkrdglllqpgtvdlmfqpaleprleeqmnqhmd
asphinyggpmpmvmrrsfglggiialedldgenwrrkgsmtfgggpniiwqidpkaglc
tlvffqlepwsdpvcrdltrtfekaiyaqyqqg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4lcmD (D:)
mvmgsnidaavaadpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrd
ennqlpplqvdtpcrlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfd
dagnprlrerrgkitlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfappl
vndpgaewiygagidwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarr
admthrnssdgklryddtvyfrhdgeecfggqgvfsspgsymkvlhsllkrdglllqpgt
vdlmfqpaleprleeqmnqhmdasphinyggpmpmvmrrsfglggiialedldgenwrrk
gsmtfgggpniiwqidpkaglctlvffqlepwsdpvcrdltrtfekaiyaqyqqghhhhh
h

    Sequence, based on observed residues (ATOM records):
    >4lcmD (D:)
dpvvlmetafrkavessqipgavlmardasgrlnytrcfgartvrrdennqlpplqvdtp
crlasatkllttimalqcmerglvrldetvdrllpdlcampvlegfddagnprlrerrgk
itlrhllthtsglsyvflhpllreyvaqghlqgaekfgiqnrfapplvndpgaewiygag
idwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradmthrnssdgkl
ryddtcfggqgvfsspgsymkvlhsllkrdglllqpgtvdlmfqpaleprleeqmnqhmd
asphinyggpmpmvmrrsfglggiialedldgenwrrkgsmtfgggpniiwqidpkaglc
tlvffqlepwsdpvcrdltrtfekaiyaqyqqg