PDB entry 4lcl

View 4lcl on RCSB PDB site
Description: simvastatin synthase (lovd), from aspergillus terreus, lovd6 mutant (simh6208)
Deposited on 2013-06-21, released 2014-04-02
The last revision was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (Start-432)
      • expression tag (9-14)
      • engineered mutation (45)
      • engineered mutation (59)
      • engineered mutation (62)
      • engineered mutation (79)
      • engineered mutation (142)
      • engineered mutation (176)
      • engineered mutation (191)
      • engineered mutation (193)
      • engineered mutation (197)
      • engineered mutation (210-211)
      • engineered mutation (260)
      • engineered mutation (266)
      • engineered mutation (269)
      • engineered mutation (294)
      • engineered mutation (316)
      • engineered mutation (380)
      • engineered mutation (389)
      • engineered mutation (402)
      • engineered mutation (423)
  • Chain 'B':
    Compound: Transesterase
    Species: Aspergillus terreus [TaxId:33178]
    Gene: lovD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y7D1 (20-432)
      • expression tag (10-14)
      • engineered mutation (28)
      • engineered mutation (45)
      • engineered mutation (59)
      • engineered mutation (62)
      • engineered mutation (79)
      • engineered mutation (142)
      • engineered mutation (176)
      • engineered mutation (191)
      • engineered mutation (193)
      • engineered mutation (197)
      • engineered mutation (210-211)
      • engineered mutation (260)
      • engineered mutation (266)
      • engineered mutation (269)
      • engineered mutation (294)
      • engineered mutation (316)
      • engineered mutation (380)
      • engineered mutation (389)
      • engineered mutation (402)
      • engineered mutation (423)
  • Heterogens: IPA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4lclA (A:)
mgsshhhhhhssglvprgshmgsiidaavaadpvvlmetafrkavesrqipgavimarda
sgrlnytrcfgartvrrdennqlpplqvdtpcrlasatkllttimalqcmerglvdldet
vdrllpdlsampvlegfddagnprlrerrgkitlrhllthtsglsyvflhpllreyvaqg
hlqgaekfgiqnrfapplvndpgaewiygagidwagklveratgldleqylqenicaplg
itdmtfklqqrpdmlarradmthrnssdgklryddsvyfradgeecfggqgvfsspgsym
kvlhsllkrdglllqpetvdlmfqpaleprleeqmnqhmdasphinyggpmpmvlrrsfg
lggiialedldgenwrrkgsmtfgggpniiwqidpkaglctlvffqlepwndpvcrdltr
tfekaiyaqyqqg

    Sequence, based on observed residues (ATOM records):
    >4lclA (A:)
hssglvadpvvlmetafrkavesrqipgavimardasgrlnytrcfgartvrrdennqlp
plqvdtpcrlasatkllttimalqcmerglvdldetvdrllpdlsampvlegfddagnpr
lrerrgkitlrhllthtsglsyvflhpllreyvaqghlnrfapplvndpgaewiygagid
wagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradmthrnssdgklry
ddsvyfradgeecfggqgvfsspgsymkvlhsllkrdglllqpetvdlmfqpaleprlee
qmnqhmdasphinyggpmpmvlrrsfglggiialedldgenwrrkgsmtfgggpniiwqi
dpkaglctlvffqlepwndpvcrdltrtfekaiyaqyqqg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4lclB (B:)
mgsshhhhhhssglvprgshmgsiidaavaadpvvlmetafrkavesrqipgavimarda
sgrlnytrcfgartvrrdennqlpplqvdtpcrlasatkllttimalqcmerglvdldet
vdrllpdlsampvlegfddagnprlrerrgkitlrhllthtsglsyvflhpllreyvaqg
hlqgaekfgiqnrfapplvndpgaewiygagidwagklveratgldleqylqenicaplg
itdmtfklqqrpdmlarradmthrnssdgklryddsvyfradgeecfggqgvfsspgsym
kvlhsllkrdglllqpetvdlmfqpaleprleeqmnqhmdasphinyggpmpmvlrrsfg
lggiialedldgenwrrkgsmtfgggpniiwqidpkaglctlvffqlepwndpvcrdltr
tfekaiyaqyqqg

    Sequence, based on observed residues (ATOM records):
    >4lclB (B:)
ssglvmgsiidaavaadpvvlmetafrkavesrqipgavimardasgrlnytrcfgartv
rrdennqlpplqvdtpcrlasatkllttimalqcmerglvdldetvdrllpdlsampvle
gfddagnprlrerrgkitlrhllthtsglsyvflhpllreyvaqghqnrfapplvndpga
ewiygagidwagklveratgldleqylqenicaplgitdmtfklqqrpdmlarradmthr
nssdgklryddsvyfradgeecfggqgvfsspgsymkvlhsllkrdglllqpetvdlmfq
paleprleeqmnqhmdasphinyggpmpmvlrrsfglggiialedldgenwrrkgsmtfg
ggpniiwqidpkaglctlvffqlepwndpvcrdltrtfekaiyaqyqqg