PDB entry 4lac

View 4lac on RCSB PDB site
Description: Crystal Structure of Protein Phosphatase 2A (PP2A) and PP2A phosphatase activator (PTPA) complex with ATPgammaS
Class: Hydrolase/signaling protein
Keywords: PP2A, PTPA, protein phosphatase, signaling pathway regulation, chaperone, Hydrolase-signaling protein complex
Deposited on 2013-06-19, released 2013-10-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-19, with a file datestamp of 2014-02-14.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: 0.191
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: PP2A Scaffold Subunit A, Truncated, an internal deletion of PP2A A
    Species: Homo sapiens [TaxId:9606]
    Gene: PP2A Phosphatase Activator
    Database cross-references and differences (RAF-indexed):
    • PDB 4LAC
  • Chain 'B':
    Compound: Serine/threonine-protein phosphatase 2A activator
    Species: Homo sapiens [TaxId:9606]
    Gene: PP2A Catalytic Subunit C, PPP2R4, PTPA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4lacb_
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PP2A Scaffold Subunit A, PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4lacc_
  • Heterogens: PEG, MN, AGS, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lacB (B:)
gsmatqnfiipkkeihtvpdmgkwkrsqayadyigfiltlnegvkgkkltfeyrvseaie
klvallntldrwidetppvdqpsrfgnkayrtwyakldeeaenlvatvvpthlaaavpev
avylkesvgnstridygtgheaafaaflcclckigvlrvddqiaivfkvfnrylevmrkl
qktyrmepagsqgvwglddfqflpfiwgssqlidhpyleprhfvdekavnenhkdymfle
cilfitemktgpfaehsnqlwnisavpswskvnqglirmykaeclekfpviqhfkfgsll
pihpvtsg

    Sequence, based on observed residues (ATOM records): (download) 
    >4lacB (B:)
qnfiipkkeihtvpdmgkwkrsqayadyigfiltlnegvkgkkltfeyrvseaieklval
lntldrwidetppvdqpsrfgnkayrtwyakldeeaenlvatvvpthlaaavpevavylk
esvgnstridygtgheaafaaflcclckigvlrvddqiaivfkvfnrylevmrklqktyr
mepagsqgvwglddfqflpfiwgssqlidhpyleprhfvdekavnenhkdymflecilfi
temktgpfaehsnqlwnisavpswskvnqglirmykaeclekfpviqhfkfgsllpihpv
t

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4lacC (C:)
gsmdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdv
hgqfhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnh
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtld
hiraldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvs
rahqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgep
hvtrrtpdyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >4lacC (C:)
kvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgqfh
dlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesrqi
tqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhiral
drlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrahql
vmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpap