PDB entry 4l9p

View 4l9p on RCSB PDB site
Description: Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Class: transferase
Keywords: Ternary complex with isoprenoid and CAAX peptide substrate, CAAX farnesyltransferase, Isoprenoid and CAAX protein/peptide substrate, transferase
Deposited on 2013-06-18, released 2014-01-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-03-26, with a file datestamp of 2014-03-21.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: 0.126
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: CaaX farnesyltransferase alpha subunit Ram2
    Species: ASPERGILLUS FUMIGATUS [TaxId:330879]
    Gene: AFUA_4G07800
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4WP27
      • engineered mutation (159)
    Domains in SCOPe 2.06: d4l9pa_
  • Chain 'B':
    Compound: CaaX farnesyltransferase beta subunit Ram1
    Species: ASPERGILLUS FUMIGATUS [TaxId:330879]
    Gene: AFUA_4G10330
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: LYS-CYS-VAL-VAL-MET (CAAX peptide)
    Database cross-references and differences (RAF-indexed):
    • PDB 4L9P (0-4)
  • Heterogens: CL, EDO, ZN, FII, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4l9pA (A:)
mgsshhhhhhsqdpmegkyssdpewasikpielndgsdfgamplatisyspeyleatsyl
ravmaanemseralrltgdiismnpahytvwiyrakilfalgkdlneeiewlnkvalkhl
knyqiwhhrqvlmssrahfptlppreqdflmemfaqdaksyhvwtyrhwlvrhfklwdhp
reiqdveallkadvrnnsawnhrymlrfgprdenefdaglhnttgpssekgrlpvvdedl
vdselqysqsrileapenrspwsyargvlqaagrplsewkdfarsfvvekqengqvvdva
vksshaiewladvyaeedgsegsaaeavkmltllkekydpirrnyweyrirqitasaaha
teisasa

    Sequence, based on observed residues (ATOM records): (download) 
    >4l9pA (A:)
gkyssdpewasikpielndgsdfgamplatisyspeyleatsylravmaanemseralrl
tgdiismnpahytvwiyrakilfalgkdlneeiewlnkvalkhlknyqiwhhrqvlmssr
ahfptlppreqdflmemfaqdaksyhvwtyrhwlvrhfklwdhpreiqdveallkadvrn
nsawnhrymlrfgprdenefdaglhnttgpssekgrlpvvdedlvdselqysqsrileap
enrspwsyargvlqaagrplsewkdfarsfvavksshaiewladvyaeedgsegsaaeav
kmltllkekydpirrnyweyrirqitasaahatei

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.