PDB entry 4l98

View 4l98 on RCSB PDB site
Description: Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175
Class: TRANSCRIPTION/TRANSCRIPTION inhibitor
Keywords: transcription factor, RXRalpha, TRANSCRIPTION-TRANSCRIPTION inhibitor complex
Deposited on 2013-06-18, released 2014-06-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-11-23, with a file datestamp of 2016-11-18.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: PPARG, NR1C3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37231 (Start-274)
      • engineered mutation (157)
    Domains in SCOPe 2.07: d4l98a_
  • Chain 'B':
    Compound: Peroxisome proliferator-activated receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: PPARG, NR1C3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37231 (4-274)
      • engineered mutation (157)
    Domains in SCOPe 2.07: d4l98b_
  • Heterogens: LRG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4l98A (A:)
    gshmesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedki
    kfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygv
    heiiytmlaslmnkdgvlisegqgfmtreflkslrkplgdfmepkfefavkfnaleldds
    dlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdl
    rqivtehvqllqvikktetdmslhpllqeiykdly
    

    Sequence, based on observed residues (ATOM records): (download)
    >4l98A (A:)
    sadlralakhlydsyiksfpltkakarailtgkttdkspfvievairifqgcqfrsveav
    qeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgvlisegqgfmtrefl
    kslrkplgdfmepkfefavkfnalelddsdlaifiaviilsgdrpgllnvkpiediqdnl
    lqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikktetdmslhpllqeiy
    kdly
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4l98B (B:)
    gshmesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedki
    kfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygv
    heiiytmlaslmnkdgvlisegqgfmtreflkslrkplgdfmepkfefavkfnaleldds
    dlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdl
    rqivtehvqllqvikktetdmslhpllqeiykdly
    

    Sequence, based on observed residues (ATOM records): (download)
    >4l98B (B:)
    esadlralakhlydsyiksfpltkakarailtgttdkspfviydmnslmmgedkikevai
    rifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgv
    lisegqgfmtreflkslrkplgdfmepkfefavkfnalelddsdlaifiaviilsgdrpg
    llnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikkt
    etdmslhpllqeiykdly