PDB entry 4l70

View 4l70 on RCSB PDB site
Description: Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0352
Class: transferase/transferase inhibitor
Keywords: DIPHTHERIA TOXIN LIKE ADP-RIBOSE TRANSFERASE, TRANSFERASE, ADP-RIBOSYLATION, transferase-transferase inhibitor complex
Deposited on 2013-06-13, released 2014-02-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-02-19, with a file datestamp of 2014-02-14.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.168
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: ADPRT3, ADPRTL3, PARP3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y6F1 (2-356)
      • expression tag (0-1)
    Domains in SCOPe 2.06: d4l70a1, d4l70a2, d4l70a3
  • Heterogens: 1V9, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4l70A (A:)
    smkrvqpcsldpatqklitnifskemfkntmalmdldvkkmplgklskqqiargfealea
    leealkgptdggqsleelsshfytviphnfghsqpppinspellqakkdmllvladiela
    qalqavseqektveevphpldrdyqllkcqlqlldsgapeykviqtyleqtgsnhrcptl
    qhiwkvnqegeedrfqahsklgnrkllwhgtnmavvaailtsglrimphsggrvgkgiyf
    asensksagyvigmkcgahhvgymflgevalgrehhintdnpslkspppgfdsviarght
    epdptqdteleldgqqvvvpqgqpvpcpefssstfsqseyliyqesqcrlryllevh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4l70A (A:)
    smkrvqpcsldpatqklitnifskemfkntmalmdldvkkmplgklskqqiargfealea
    leealkdggqsleelsshfytviphnfghsqpppinspellqakkdmllvladielaqal
    qavseqektveevphpldrdyqllkcqlqlldsgapeykviqtyleqtgsnhrcptlqhi
    wkvnqegeedrfqahsklgnrkllwhgtnmavvaailtsglrimphsggrvgkgiyfase
    nsksagyvigmkcgahhvgymflgevalgrehhintdnpslkspppgfdsviarghtepd
    ptqdteleldgqqvvvpqgqpvpcpefssstfsqseyliyqesqcrlryllevh