PDB entry 4l5b

View 4l5b on RCSB PDB site
Description: Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
Class: transferase/transferase inhibitor
Keywords: phosphoryl transfer, phosphorylation, deoxycytidine kinase, transferase-transferase inhibitor complex
Deposited on 2013-06-10, released 2013-09-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-11-27, with a file datestamp of 2013-11-22.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: 0.19
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered mutation (64)
      • engineered mutation (78)
      • engineered mutation (93)
      • engineered mutation (165)
    Domains in SCOPe 2.08: d4l5ba_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered mutation (64)
      • engineered mutation (78)
      • engineered mutation (93)
      • engineered mutation (165)
    Domains in SCOPe 2.08: d4l5bb_
  • Heterogens: 1UX, UDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4l5bA (A:)
mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
lkqlsedwevvpepvarwsnvqstqdefeeltmeqknggnvlqmmyekperwsftfqtya
clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >4l5bA (A:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnltmeqknggnvlqmmyekp
erwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmne
tewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklh
ykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4l5bB (B:)
mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
lkqlsedwevvpepvarwsnvqstqdefeeltmeqknggnvlqmmyekperwsftfqtya
clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >4l5bB (B:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsltmeqknggnvlqmmyekpe
rwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnet
ewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhy
kheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl