PDB entry 4l53

View 4l53 on RCSB PDB site
Description: crystal structure of (1r,4r)-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7- yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}cyclohexan-1-ol bound to tak1-tab1
Deposited on 2013-06-10, released 2013-07-03
The last revision was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K7, TAK1, MAP3K7IP1, TAB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43318 (5-277)
      • expression tag (0-4)
    • Uniprot Q15750 (278-306)
  • Heterogens: 1UO, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4l53A (A:)
gslhmidykeieveevvgrgafgvvckakwrakdvaikqieseserkafivelrqlsrvn
hpnivklygaclnpvclvmeyaeggslynvlhgaeplpyytaahamswclqcsqgvaylh
smqpkalihrdlkppnlllvaggtvlkicdfgtacdiqthmtnnkgsaawmapevfegsn
ysekcdvfswgiilwevitrrkpfdeiggpafrimwavhngtrppliknlpkpieslmtr
cwskdpsqrpsmeeivkimthlmryfpgadeplqypcqhslppgedgrvepyvdfaefyr
lwsvdhg

    Sequence, based on observed residues (ATOM records):
    >4l53A (A:)
gslhmidykeieveevvgrgafgvvckakwrakdvaikqieseserkafivelrqlsrvn
hpnivklygaclnpvclvmeyaeggslynvlhgaeplpyytaahamswclqcsqgvaylh
smqpkalihrdlkppnlllvaggtvlkicdfgtkgsaawmapevfegsnysekcdvfswg
iilwevitrrkpfdeiggpafrimwavhngtrppliknlpkpieslmtrcwskdpsqrps
meeivkimthlmryfpgadeplqypcqhslppgedgrvepyvdfaefyrlwsvdhg