PDB entry 4l4t

View 4l4t on RCSB PDB site
Description: Structure of human MAIT TCR in complex with human MR1-6-FP
Class: Membrane Protein/Immune System
Keywords: MHC Class I-related protein, MAIT TCR, Immune System, Vitamin B metabolites, Membrane Protein-Immune System complex
Deposited on 2013-06-09, released 2013-07-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-09-11, with a file datestamp of 2013-09-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.186
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-End)
      • expression tag (0)
      • engineered mutation (261)
    Domains in SCOPe 2.06: d4l4ta1, d4l4ta2, d4l4ta3
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4l4tb_
  • Chain 'C':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-End)
      • expression tag (0)
      • engineered mutation (261)
    Domains in SCOPe 2.06: d4l4tc1, d4l4tc2, d4l4tc3
  • Chain 'D':
    Compound: MAIT T-cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR alpha
    Database cross-references and differences (RAF-indexed):
    • PDB 4L4T (0-End)
    Domains in SCOPe 2.06: d4l4td1, d4l4td2
  • Chain 'E':
    Compound: MAIT T-cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR beta
    Database cross-references and differences (RAF-indexed):
    • PDB 4L4T
    Domains in SCOPe 2.06: d4l4te1, d4l4te2
  • Chain 'F':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4l4tf_
  • Chain 'G':
    Compound: MAIT T-cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR alpha
    Database cross-references and differences (RAF-indexed):
    • PDB 4L4T (0-End)
    Domains in SCOPe 2.06: d4l4tg1, d4l4tg2
  • Chain 'H':
    Compound: MAIT T-cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR beta
    Database cross-references and differences (RAF-indexed):
    • PDB 4L4T
    Domains in SCOPe 2.06: d4l4th1, d4l4th2
  • Heterogens: 6FP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4l4tA (A:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasieldpqssnlyschvehsgvhmvlqvp

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tA (A:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasiellyschvehsgvhmvlqv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4l4tB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4l4tC (C:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasieldpqssnlyschvehsgvhmvlqvp

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tC (C:)
mrthslryfrlgvsdpivpefisvgyvdshpittydsvtrqkeprapwmaenlapdhwer
ytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdfli
fnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrtep
plvrvnralfckahgfyppeiymtwmkngeidygdilpsgdgtyqawasiesnlyschve
hsgvhmvlqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4l4tD (D:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tD (D:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpsp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4l4tE (E:)
nagvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgev
pngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlkn
vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
wgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tE (E:)
agvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgevp
ngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gra

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4l4tF (F:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tF (F:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdr

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4l4tG (G:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tG (G:)
gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
lrdsksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsndfacanaf
nnsiipedtffps

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4l4tH (H:)
nagvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgev
pngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlkn
vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
wgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4tH (H:)
gvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgevpn
gynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlknvf
ppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqp
alndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg
ra