PDB entry 4l4l

View 4l4l on RCSB PDB site
Description: Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase
Class: Transferase/Transferase Inhibitor
Keywords: Transferase, inhibitor PRPP adduct, active site, Transferase-Transferase Inhibitor complex
Deposited on 2013-06-08, released 2014-06-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: 0.189
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4l4la1, d4l4la2
  • Chain 'B':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4l4lb1, d4l4lb2
  • Heterogens: 1XC, PO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4l4lA (A:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4lA (A:)
efnillatdsykvthykqyppntskvysyfecrekkkyeetvfyglqyilnkylkgkvvt
kekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftven
tdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyr
gvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkd
hekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgn
pldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsie
niafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtp
agnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlnielea

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4l4lB (B:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4l4lB (B:)
efnillatdsykvthykqyppntskvysyfecrekvkyeetvfyglqyilnkylkgkvvt
kekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftven
tdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyr
gvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkd
hekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgn
pldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsie
niafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtp
agnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlnieleaa