PDB entry 4l3o

View 4l3o on RCSB PDB site
Description: Crystal Structure of SIRT2 in complex with the macrocyclic peptide S2iL5
Deposited on 2013-06-06, released 2014-02-19
The last revision was dated 2014-02-19, with a file datestamp of 2014-02-14.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: 0.216
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: nad-dependent protein deacetylase sirtuin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: nad-dependent protein deacetylase sirtuin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: nad-dependent protein deacetylase sirtuin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: nad-dependent protein deacetylase sirtuin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: cyclic peptide S2iL5
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4L3O (0-End)
  • Chain 'F':
    Compound: cyclic peptide S2iL5
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4L3O (0-End)
  • Chain 'G':
    Compound: cyclic peptide S2iL5
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4L3O (0-End)
  • Chain 'H':
    Compound: cyclic peptide S2iL5
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 4L3O (0-End)
  • Heterogens: ZN, MES, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4l3oA (A:)
kerlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpy
peaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtler
iagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivf
fgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsd
pflgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasida
qs

    Sequence, based on observed residues (ATOM records):
    >4l3oA (A:)
kerlldeltlegvarymqsercrrviclvgagistsagipdfrsydnlekyhlpypeaif
eisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleriagle
qedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivffgesl
parffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdpflgm
imglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4l3oB (B:)
kerlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpy
peaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtler
iagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivf
fgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsd
pflgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasida
qs

    Sequence, based on observed residues (ATOM records):
    >4l3oB (B:)
erlldeltlegvarymqsercrrviclvgagistsagipdfrspslekyhlpypeaifei
syfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleriagleqe
dlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivffgeslpa
rffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdpflgmim
glgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4l3oC (C:)
kerlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpy
peaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtler
iagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivf
fgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsd
pflgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasida
qs

    Sequence, based on observed residues (ATOM records):
    >4l3oC (C:)
rlldeltlegvarymqsercrrviclvgagistsagipdfrspnlekyhlpypeaifeis
yfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleriagleqed
lveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivffgeslpar
ffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdpflgmimg
lgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4l3oD (D:)
kerlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpy
peaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtler
iagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivf
fgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsd
pflgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasida
qs

    Sequence, based on observed residues (ATOM records):
    >4l3oD (D:)
rlldeltlegvarymqsercrrviclvgagistsagipdfrsnlekyhlpypeaifeisy
fkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleriagleqedl
veahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivffgeslparf
fscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdpflgmimgl
gggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >4l3oE (E:)
xyhtyhvxrrtnyyc

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >4l3oF (F:)
xyhtyhvxrrtnyyc

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >4l3oG (G:)
xyhtyhvxrrtnyyc

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >4l3oH (H:)
xyhtyhvxrrtnyyc