PDB entry 4l3e

View 4l3e on RCSB PDB site
Description: The complex between high affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(26-35)(A27L) peptide
Deposited on 2013-06-05, released 2014-06-11
The last revision was dated 2014-08-27, with a file datestamp of 2014-08-22.
Experiment type: XRAY
Resolution: 2.56 Å
R-factor: 0.231
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
  • Chain 'C':
    Compound: Melanoma antigen recognized by T-cells 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16655 (0-9)
      • engineered mutation (1)
  • Chain 'D':
    Compound: DMF5 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC, TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 4L3E (0-198)
  • Chain 'E':
    Compound: DMF5 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4L3E (0-241)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >4l3eA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >4l3eB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >4l3eC (C:)
elagigiltv

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >4l3eD (D:)
keveqnsgplsvpegaiaslnctysyrgsqsffwyrqysgkspelimfiysngdkedgrf
taqlnkasqyvsllirdsqpsdsatylcavnfgggklifgqgtelsvkpniqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffps

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >4l3eE (E:)
iagitqaptsqilaagrrmtlrctqdmrhnamywyrqdlglglrlihysntagttgkgev
pdgysvsrantddfpltlasavpsqtsvyfcasswsfgteaffgqgtrltvvedlnkvfp
pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgr
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