PDB entry 4l23

View 4l23 on RCSB PDB site
Description: crystal structure of p110alpha complexed with nish2 of p85alpha and pi-103
Deposited on 2013-06-04, released 2014-01-01
The last revision was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB1, PIK3R1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: X6K, SO4, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4l23A (A:)
mpprpssgelwgihlmpprilvecllpngmivtleclreatlitikhelfkearkyplhq
llqdessyifvsvtqeaereeffdetrrlcdlrlfqpflkviepvgnreekilnreigfa
igmpvcefdmvkdpevqdfrrnilnvckeavdlrdlnsphsramyvyppnvesspelpkh
iynkldkgqiivviwvivspnndkqkytlkinhdcvpeqviaeairkktrsmllsseqlk
lcvleyqgkyilkvcgcdeyflekyplsqykyirscimlgrmpnlmlmakeslysqlpmd
cftmpsysrristatpymngetstkslwvinsalrikilcatyvnvnirdidkiyvrtgi
yhggeplcdnvntqrvpcsnprwnewlnydiyipdlpraarlclsicsvkgrkgakeehc
plawgninlfdytdtlvsgkmalnlwpvphgledllnpigvtgsnpnketpclelefdwf
ssvvkfpdmsvieehanwsvsreagfsyshaglsnrlardnelrendkeqlkaistrdpl
seiteqekdflwshrhycvtipeilpklllsvkwnsrdevaqmyclvkdwppikpeqame
lldcnypdpmvrgfavrclekyltddklsqyliqlvqvlkyeqyldnllvrfllkkaltn
qrighfffwhlksemhnktvsqrfglllesycracgmylkhlnrqveameklinltdilk
qekkdetqkvqmkflveqmrrpdfmdalqgflsplnpahqlgnlrleecrimssakrplw
lnwenpdimsellfqnneiifkngddlrqdmltlqiirimeniwqnqgldlrmlpygcls
igdcvglievvrnshtimqiqckgglkgalqfnshtlhqwlkdknkgeiydaaidlftrs
cagycvatfilgigdrhnsnimvkddgqlfhidfghfldhkkkkfgykrervpfvltqdf
liviskgaqectktreferfqemcykaylairqhanlfinlfsmmlgsgmpelqsfddia
yirktlaldkteqealeyfmkqmndahhggwttkmdwifhtikqhaln

    Sequence, based on observed residues (ATOM records):
    >4l23A (A:)
gelwgihlmpprilvecllpngmivtleclreatlitikhelfkearkyplhqllqdess
yifvsvtqeaereeffdetrrlcdlrlfqpflkviepvgnreekilnreigfaigmpvce
fdmvkdpevqdfrrnilnvckeavdlrdlnsphsramyvyppnvesspelpkhiynkldk
gqiivviwvivspnndkqkytlkinhdcvpeqviaeairkllsseqlklcvleyqgkyil
kvcgcdeyflekyplsqykyirscimlgrmpnlmlmakeslysqlpmdcftmpsysgets
tkslwvinsalrikilcatyvnvnirdidkiyvrtgiyhggeplcdnvntqrvpcsnprw
newlnydiyipdlpraarlclsicsvkgakeehcplawgninlfdytdtlvsgkmalnlw
pvphgledllnpigvtgsnpnketpclelefdwfssvvkfpdmsvieehanwsvsreanr
lardnelrendkeqlkaistrdplseiteqekdflwshrhycvtipeilpklllsvkwns
rdevaqmyclvkdwppikpeqamelldcnypdpmvrgfavrclekyltddklsqyliqlv
qvlkyeqyldnllvrfllkkaltnqrighfffwhlksemhnktvsqrfglllesycracg
mylkhlnrqveameklinltdilkqekkdetqkvqmkflveqmrrpdfmdalqgflspln
pahqlgnlrleecrimssakrplwlnwenpdimsellfqnneiifkngddlrqdmltlqi
irimeniwqnqgldlrmlpygclsigdcvglievvrnshtimqiqcknshtlhqwlkdkn
kgeiydaaidlftrscagycvatfilgigdrhnsnimvkddgqlfhidfghfldhkkkkf
gykrervpfvltqdfliviskgaqectktreferfqemcykaylairqhanlfinlfsmm
lgsgmpelqsfddiayirktlaldkteqealeyfmkqmndahhggwttkmdwif

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4l23B (B:)
msyyhhhhhhdydipttenlyfqsiaanngmnnnmslqdaewywgdisreevneklrdta
dgtflvrdastkmhgdytltlrkggnnklikifhrdgkygfsdpltfssvvelinhyrne
slaqynpkldvkllypvskyqqdqvvkednieavgkklheyntqfqeksreydrlyeeyt
rtsqeiqmkrtaieafnetikifeeqcqtqeryskeyiekfkregnekeiqrimhnydkl
ksriseiidsrrrleedlkkqaaeyreidkrmnsikpdliqlrktrdqylmwltqkgvrq
kklnewlgnentedqyslvedded

    Sequence, based on observed residues (ATOM records):
    >4l23B (B:)
mnnnmslqdaewywgdisreevneklrdtadgtflvrdastkmhgdytltlrkggnnkli
kifhrdgkygfsdpltfssvvelinhyrneslaqynpkldvkllypvskyqqdqvvkedn
ieavgkklheyntqfqeksreydrlyeeytrtsqeiqmkrtaieafnetikifeeqcqtq
eryskeyiekfkregnekeiqrimhnydklksriseiidsrrrleedlkkqaaeyreidk
rmnsikpdliqlrktrdqylmwltqkgvrqkklnewl