PDB entry 4l1x

View 4l1x on RCSB PDB site
Description: Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone
Class: oxidoreductase
Keywords: alpha-beta barrel, human 3-alpha hsd3, akr, akr1c2,oxidoreductase, aldo-keto reductase, nadph, oxidoreductase
Deposited on 2013-06-03, released 2014-04-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-16, with a file datestamp of 2014-04-11.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.142
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member C2
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52895 (3-324)
      • expression tag (0-2)
      • engineered mutation (55)
    Domains in SCOPe 2.08: d4l1xa1, d4l1xa2
  • Chain 'B':
    Compound: Aldo-keto reductase family 1 member C2
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52895 (3-324)
      • expression tag (0-2)
      • engineered mutation (55)
    Domains in SCOPe 2.08: d4l1xb1, d4l1xb2
  • Heterogens: NAP, STR, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4l1xA (A:)
svddskyqcvklndghfmpvlgfgtyapaevpkskaleavklaieagfhhidsahlynne
eqvglairskiadgsvkredifytsklwsnshrpelvrpalerslknlqldyvdlylihf
pvsvkpgeevipkdengkilfdtvdlcatweamekckdaglaksigvsnfnhrllemiln
kpglkykpvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlled
pvlcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidg
lnrnvryltldifagppnypfsdey

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4l1xB (B:)
svddskyqcvklndghfmpvlgfgtyapaevpkskaleavklaieagfhhidsahlynne
eqvglairskiadgsvkredifytsklwsnshrpelvrpalerslknlqldyvdlylihf
pvsvkpgeevipkdengkilfdtvdlcatweamekckdaglaksigvsnfnhrllemiln
kpglkykpvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlled
pvlcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidg
lnrnvryltldifagppnypfsdey