PDB entry 4l1a

View 4l1a on RCSB PDB site
Description: Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance
Class: hydrolase/hydrolase inhibitor
Keywords: HIV-1 protease, Multi-drug resistance, IC50, Lopinavir, protease, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-06-03, released 2014-04-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-02, with a file datestamp of 2014-03-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.201
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: MDR769 HIV-1 protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q000H7 (0-98)
    • variant (24)
    • variant (34-35)
    • variant (45)
  Domains in SCOPe 2.08: d4l1aa_
• Chain 'B':
  Compound: MDR769 HIV-1 protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q000H7 (0-98)
    • variant (24)
    • variant (34-35)
    • variant (45)
    • variant (70)
  Domains in SCOPe 2.08: d4l1ab_
• Heterogens: AB1, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4l1aA (A:)
  pqitlwqrpivtikiggqlkeallntgaddtvleevnlpgrwkpkliggiggfvkvrqyd
  qvpieicghkvigtvlvgptptnvigrnlmtqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4l1aB (B:)
  pqitlwqrpivtikiggqlkeallntgaddtvleevnlpgrwkpkliggiggfvkvrqyd
  qvpieicghktigtvlvgptptnvigrnlmtqigctlnf