PDB entry 4l18

View 4l18 on RCSB PDB site
Description: Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3)
Deposited on 2013-06-02, released 2014-03-26
The last revision was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.231
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: runt-related transcription factor 1
    Species: Mus musculus [TaxId:10090]
    Gene: Runx1, Aml1, Cbfa2, Pebp2ab
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Protein C-ets-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ETS1, EWSR2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: 5'-d(*gp*gp*ap*ap*gp*cp*cp*ap*cp*ap*tp*cp*cp*tp*cp*t)-3'
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'D':
    Compound: 5'-d(*cp*ap*gp*ap*gp*gp*ap*tp*gp*tp*gp*gp*cp*tp*tp*c)-3'
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'E':
    Compound: runt-related transcription factor 1
    Species: Mus musculus [TaxId:10090]
    Gene: Runx1, Aml1, Cbfa2, Pebp2ab
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Protein C-ets-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ETS1, EWSR2
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: 5'-d(*gp*gp*ap*ap*gp*cp*cp*ap*cp*ap*tp*cp*cp*tp*cp*t)-3'
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'H':
    Compound: 5'-d(*cp*ap*gp*ap*gp*gp*ap*tp*gp*tp*gp*gp*cp*tp*tp*c)-3'
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Heterogens: GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4l18A (A:)
drsmvevladhpgelvrtdspnflcsvlpthwrcnktlpiafkvvalgdvpdgtlvtvma
gndenysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhraik
itvdgpreprrhrqklddqtkpgslsfserlseleqlrrtamrvsph

    Sequence, based on observed residues (ATOM records):
    >4l18A (A:)
evladhpgelvrtdspnflcsvlpthwrcnktlpiafkvvalgdvpdgtlvtvmagnden
ysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhraikitvdg
preprpgslsfserlseleqlr

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4l18B (B:)
pnhkpkgtfkdyvrdradlnkdkpvipaaalagytgsgpiqlwqfllelltdkscqsfis
wtgdgwefklsdpdevarrwgkrknkpkmnyeklsrglryyydkniihktagkryvyrfv
cdlqsllgytpeelhamldvkpdade

    Sequence, based on observed residues (ATOM records):
    >4l18B (B:)
gpiqlwqfllelltdkscqsfiswtgdgwefklsdpdevarrwgkrknkpkmnyeklsrg
lryyydkniihktagkryvyrfvcdlqsllgytpeelhamldvkpda

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4l18E (E:)
drsmvevladhpgelvrtdspnflcsvlpthwrcnktlpiafkvvalgdvpdgtlvtvma
gndenysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhraik
itvdgpreprrhrqklddqtkpgslsfserlseleqlrrtamrvsph

    Sequence, based on observed residues (ATOM records):
    >4l18E (E:)
vevladhpgelvrtdspnflcsvlpthwrcnktlpiafkvvalgdvpdgtlvtvmagnde
nysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhraikitvd
gpreprgslsfserlseleql

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4l18F (F:)
pnhkpkgtfkdyvrdradlnkdkpvipaaalagytgsgpiqlwqfllelltdkscqsfis
wtgdgwefklsdpdevarrwgkrknkpkmnyeklsrglryyydkniihktagkryvyrfv
cdlqsllgytpeelhamldvkpdade

    Sequence, based on observed residues (ATOM records):
    >4l18F (F:)
sgpiqlwqfllelltdkscqsfiswtgdgwefklsdpdevarrwgkrknkpkmnyeklsr
glryyydkniihktagkryvyrfvcdlqsllgytpeelhamldvkp

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.