PDB entry 4l01

View 4l01 on RCSB PDB site
Description: Crystal structure of the V658F apo Jak1 pseudokinase domain
Class: transferase
Keywords: kinase domain fold, regulatory, TRANSFERASE
Deposited on 2013-05-30, released 2013-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.204
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23458
      • engineered mutation (101)
    Domains in SCOPe 2.08: d4l01a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23458
      • engineered mutation (101)
    Domains in SCOPe 2.08: d4l01b_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4l01A (A:)
gstsaqewqpvypmsqlsfdrilkkdlvqgehlgrgtrthiysgtlmdykddegtseekk
ikvilkvldpshrdislaffeaasmmrqvshkhivylygvcfrdvenimveefveggpld
lfmhrksdvlttpwkfkvakqlasalsyledkdlvhgnvctknlllaregidsecgpfik
lsdpgipitvlsrqecieripwiapecvedsknlsvaadkwsfgttlweicyngeiplkd
ktliekerfyesrcrpvtpsckeladlmtrcmnydpnqrpffraimrdinkleeqnpdiv
sekk

    Sequence, based on observed residues (ATOM records): (download) 
    >4l01A (A:)
qpvypmsqlsfdrilkkdlvqgehlgrgtrthiysgtlmdkkikvilkvldpshrdisla
ffeaasmmrqvshkhivylygvcfrdvenimveefveggpldlfmhrksdvlttpwkfkv
akqlasalsyledkdlvhgnvctknlllaregidcgpfiklsdpgipitvlsrqecieri
pwiapecvedsknlsvaadkwsfgttlweicyngeiplkdktliekerfyesrcrpvtps
ckeladlmtrcmnydpnqrpffraimrdinklee

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4l01B (B:)
gstsaqewqpvypmsqlsfdrilkkdlvqgehlgrgtrthiysgtlmdykddegtseekk
ikvilkvldpshrdislaffeaasmmrqvshkhivylygvcfrdvenimveefveggpld
lfmhrksdvlttpwkfkvakqlasalsyledkdlvhgnvctknlllaregidsecgpfik
lsdpgipitvlsrqecieripwiapecvedsknlsvaadkwsfgttlweicyngeiplkd
ktliekerfyesrcrpvtpsckeladlmtrcmnydpnqrpffraimrdinkleeqnpdiv
sekk

    Sequence, based on observed residues (ATOM records): (download) 
    >4l01B (B:)
qpvypmsqlsfdrilkkdlvqgehlgrgtrthiysgtlmdkkikvilkvldpshrdisla
ffeaasmmrqvshkhivylygvcfrvenimveefveggpldlfmhrksdvlttpwkfkva
kqlasalsyledkdlvhgnvctknlllaregidsecgpfiklsdpgipitvlsrqecier
ipwiapecvedsknlsvaadkwsfgttlweicyngeiplkdktliekerfyesrcrpvtp
sckeladlmtrcmnydpnqrpffraimrdinkle