PDB entry 4kyo

View 4kyo on RCSB PDB site
Description: Alanine-glyoxylate aminotransferase variant K390A in complex with the TPR domain of human Pex5p
Class: transferase/transport protein
Keywords: TPR-domain, aminotransferase, pyruvate, transport, peroxisomal import, primary hyperoxaluria, peroxisome, TRANSFERASE-TRANSPORT PROTEIN complex
Deposited on 2013-05-29, released 2014-11-19
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.177
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine-pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549 (Start-393)
      • engineered mutation (391)
    Domains in SCOPe 2.04: d4kyoa_
  • Chain 'B':
    Compound: peroxisomal targeting signal 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PEX5, PXR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4kyob_
  • Chain 'C':
    Compound: Serine-pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549 (Start-393)
      • engineered mutation (391)
    Domains in SCOPe 2.04: d4kyoc_
  • Chain 'D':
    Compound: peroxisomal targeting signal 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PEX5, PXR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4kyod_
  • Heterogens: SO4, BTB, BME, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kyoA (A:)
gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
lllvdsvaslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
lrigllgcnatrenvdrvtealraalqhcpkakl

    Sequence, based on observed residues (ATOM records): (download) 
    >4kyoA (A:)
llvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegiq
yvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvhp
mtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvdsv
aslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldik
wlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqal
glqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigllg
cnatrenvdrvtealraalqhcpkakl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4kyoB (B:)
gamltsatydkgyqfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmea
wqylgttqaeneqellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlr
ytpayahlvtpaeegaggaglgpskrilgsllsdslflevkelflaavrldptsidpdvq
cglgvlfnlsgeydkavdcftaalsvrpndyllwnklgatlangnqseeavaayrralel
qpgyirsrynlgiscinlgahreavehflealnmqrksrgprgeggamseniwstlrlal
smlgqsdaygaadardlstlltmfglpq

    Sequence, based on observed residues (ATOM records): (download) 
    >4kyoB (B:)
qfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmeawqylgttqaeneq
ellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlrytpayahlvdslf
levkelflaavrldptsidpdvqcglgvlfnlsgeydkavdcftaalsvrpndyllwnkl
gatlangnqseeavaayrralelqpgyirsrynlgiscinlgahreavehflealnmqrk
seggamseniwstlrlalsmlgqsdaygaadardlstlltmfglpq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4kyoC (C:)
gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
lllvdsvaslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
lrigllgcnatrenvdrvtealraalqhcpkakl

    Sequence, based on observed residues (ATOM records): (download) 
    >4kyoC (C:)
kllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegi
qyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvh
pmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvds
vaslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldi
kwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqa
lglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigll
gcnatrenvdrvtealraalqhcpkakl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4kyoD (D:)
gamltsatydkgyqfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmea
wqylgttqaeneqellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlr
ytpayahlvtpaeegaggaglgpskrilgsllsdslflevkelflaavrldptsidpdvq
cglgvlfnlsgeydkavdcftaalsvrpndyllwnklgatlangnqseeavaayrralel
qpgyirsrynlgiscinlgahreavehflealnmqrksrgprgeggamseniwstlrlal
smlgqsdaygaadardlstlltmfglpq

    Sequence, based on observed residues (ATOM records): (download) 
    >4kyoD (D:)
qfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmeawqylgttqaeneq
ellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlrytpayahlvdslf
levkelflaavrldptsidpdvqcglgvlfnlsgeydkavdcftaalsvrpndyllwnkl
gatlangnqseeavaayrralelqpgyirsrynlgiscinlgahreavehflealnmqrk
sggamseniwstlrlalsmlgqsdaygaadardlstlltmfglpq