PDB entry 4kxk

View 4kxk on RCSB PDB site
Description: Alanine-glyoxylate aminotransferase variant K390A/K391A in complex with the TPR domain of human Pex5p
Class: transferase/transport protein
Keywords: TPR-domain, aminotransferase, pyruvate, transport, peroxisomal import, primary hyperoxaluria, Peroxisome, TRANSFERASE-TRANSPORT PROTEIN complex
Deposited on 2013-05-27, released 2014-11-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-01-14, with a file datestamp of 2015-01-09.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.187
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine--pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549 (Start-393)
      • engineered mutation (391-392)
    Domains in SCOPe 2.07: d4kxka_
  • Chain 'B':
    Compound: peroxisomal targeting signal 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PEX5, PXR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kxkb_
  • Chain 'C':
    Compound: Serine--pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549 (Start-393)
      • engineered mutation (391-392)
    Domains in SCOPe 2.07: d4kxkc_
  • Chain 'D':
    Compound: peroxisomal targeting signal 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PEX5, PXR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kxkd_
  • Heterogens: SO4, BME, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4kxkA (A:)
    gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
    eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
    igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
    lllvdsvaslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
    sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
    hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
    lrigllgcnatrenvdrvtealraalqhcpkaal
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kxkA (A:)
    llvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegiq
    yvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvhp
    mtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvdsv
    aslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldik
    wlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqal
    glqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigllg
    cnatrenvdrvtealraalqhcpkaal
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4kxkB (B:)
    gamltsatydkgyqfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmea
    wqylgttqaeneqellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlr
    ytpayahlvtpaeegaggaglgpskrilgsllsdslflevkelflaavrldptsidpdvq
    cglgvlfnlsgeydkavdcftaalsvrpndyllwnklgatlangnqseeavaayrralel
    qpgyirsrynlgiscinlgahreavehflealnmqrksrgprgeggamseniwstlrlal
    smlgqsdaygaadardlstlltmfglpq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kxkB (B:)
    qfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmeawqylgttqaeneq
    ellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlrytpayahlvdslf
    levkelflaavrldptsidpdvqcglgvlfnlsgeydkavdcftaalsvrpndyllwnkl
    gatlangnqseeavaayrralelqpgyirsrynlgiscinlgahreavehflealnmqrk
    srgeggamseniwstlrlalsmlgqsdaygaadardlstlltmfglpq
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4kxkC (C:)
    gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
    eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
    igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
    lllvdsvaslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
    sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
    hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
    lrigllgcnatrenvdrvtealraalqhcpkaal
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kxkC (C:)
    llvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegiq
    yvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvhp
    mtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvdsv
    aslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldik
    wlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqal
    glqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigllg
    cnatrenvdrvtealraalqhcpkaal
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4kxkD (D:)
    gamltsatydkgyqfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmea
    wqylgttqaeneqellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlr
    ytpayahlvtpaeegaggaglgpskrilgsllsdslflevkelflaavrldptsidpdvq
    cglgvlfnlsgeydkavdcftaalsvrpndyllwnklgatlangnqseeavaayrralel
    qpgyirsrynlgiscinlgahreavehflealnmqrksrgprgeggamseniwstlrlal
    smlgqsdaygaadardlstlltmfglpq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kxkD (D:)
    qfeeenplrdhpqpfeeglrrlqegdlpnavllfeaavqqdpkhmeawqylgttqaeneq
    ellaisalrrclelkpdnqtalmalavsftneslqrqacetlrdwlrytpayahlvdslf
    levkelflaavrldptsidpdvqcglgvlfnlsgeydkavdcftaalsvrpndyllwnkl
    gatlangnqseeavaayrralelqpgyirsrynlgiscinlgahreavehflealnmqrk
    srgeggamseniwstlrlalsmlgqsdaygaadardlstlltmfglpq