PDB entry 4kwg

View 4kwg on RCSB PDB site
Description: Crystal Structure Analysis of ALDH2+ALDiB13
Class: OXIDOREDUCTASE/Inhibitor
Keywords: ALDH2+B13, ketone binding, OXIDOREDUCTASE-Inhibitor complex
Deposited on 2013-05-24, released 2014-04-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwga_
  • Chain 'B':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwgb_
  • Chain 'C':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwgc_
  • Chain 'D':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwgd_
  • Chain 'E':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwge_
  • Chain 'F':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwgf_
  • Chain 'G':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwgg_
  • Chain 'H':
    Compound: aldehyde dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH2, ALDM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kwgh_
  • Heterogens: 2AK, NA, EDO, GAI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgA (A:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgB (B:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgC (C:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgD (D:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgE (E:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgF (F:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgG (G:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4kwgH (H:)
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayt
evktvtvkvpqkns