PDB entry 4kvp

View 4kvp on RCSB PDB site
Description: Human p53 Core Domain Mutant V157F
Class: apoptosis
Keywords: Tumor Suppressor Protein p53, Cancer Mutation, Tumor, Protein Stability, Mutant Proteins, APOPTOSIS
Deposited on 2013-05-22, released 2013-07-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-17, with a file datestamp of 2019-07-12.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (64)
    Domains in SCOPe 2.08: d4kvpa_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (64)
    Domains in SCOPe 2.08: d4kvpb_
  • Chain 'C':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (64)
    Domains in SCOPe 2.08: d4kvpc_
  • Chain 'D':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (64)
    Domains in SCOPe 2.08: d4kvpd_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kvpA (A:)
asssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpp
pgtrframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntf
rhsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfev
rvcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4kvpA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4kvpB (B:)
asssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpp
pgtrframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntf
rhsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfev
rvcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4kvpB (B:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4kvpC (C:)
asssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpp
pgtrframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntf
rhsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfev
rvcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4kvpC (C:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4kvpD (D:)
asssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpp
pgtrframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntf
rhsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfev
rvcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4kvpD (D:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rframaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl