PDB entry 4kuf
View 4kuf on RCSB PDB site
Description: Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134 mutant with MTSEA modified Cys-165 causing stretch disorder
Class: hydrolase
Keywords: Clostridial neurotoxin zinc protease, Peptidase_M27, SNAP 25, covalent inhibition, HYDROLASE
Deposited on
2013-05-22, released
2014-07-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-07-17, with a file datestamp of
2019-07-12.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Botulinum neurotoxin A light chain
Species: Clostridium botulinum A [TaxId:441771]
Gene: botA, CBO0806, CLC_0862
Database cross-references and differences (RAF-indexed):
- Uniprot A5HZZ9 (20-444)
- expression tag (19)
- engineered mutation (153)
Domains in SCOPe 2.08: d4kufa1, d4kufa2 - Heterogens: ZN, DMS, LMR, GOL, EDO, NA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4kufA (A:)
mgsshhhhhhssglvprgshmpfvnkqfnykdpvngvdiayikipnagqmqpvkafkihn
kiwviperdtftnpeegdlnpppeakqvpvsyydstylstdnekdnylkgvtklferiys
tdlgrmlltsivrgipfwggstidtelkvidtnsinviqpdgsyrseelnlviigpsadi
iqfexksfghevlnltrngygstqyirfspdftfgfeeslevdtnpllgagkfatdpavt
lahelihaghrlygiainpnrvfkvntnayyemsglevsfeelrtfgghdakfidslqen
efrlyyynkfkdiastlnkaksivgttaslqymknvfkekyllsedtsgkfsvdklkfdk
lykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaan
fngqnteinnmnftklknftglfef
Sequence, based on observed residues (ATOM records): (download)
>4kufA (A:)
hmpfvnkqfnykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeegdl
npppeakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwg
gstidtelkvidtnsinviqpdgsyrseelnlviigpsadiiqfexksfghevlnltrng
ygstqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihaghrlygiainp
nrvfkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnk
aksivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffk
vlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinnmnftklknf
tglfef