PDB entry 4ktt

View 4ktt on RCSB PDB site
Description: Structural insights of MAT enzymes: MATa2b complexed with SAM
Class: transferase
Keywords: SAMe Synthesis, TRANSFERASE
Deposited on 2013-05-21, released 2014-07-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-09-24, with a file datestamp of 2014-09-19.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: 0.221
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ktta1, d4ktta2, d4ktta3
  • Chain 'B':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4kttb1, d4kttb2, d4kttb3
  • Chain 'C':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4kttc1, d4kttc2, d4kttc3
  • Chain 'D':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4kttd1, d4kttd2, d4kttd3
  • Chain 'E':
    Compound: methionine adenosyltransferase 2 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ktte_
  • Chain 'F':
    Compound: methionine adenosyltransferase 2 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4kttf_
  • Heterogens: EDO, SAM, PO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kttA (A:)
smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >4kttA (A:)
egtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsr
aavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspqglmfgyatdeteecmplt
ivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvqhdeev
cldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpqgdagltgrkiivdtygg
wgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaishplsisifhy
gtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4kttB (B:)
smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >4kttB (B:)
eegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageits
raavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigag
dqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrg
avlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfvig
gpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrr
vlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqr
taayghfgrdsfpwevpkklky

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4kttC (C:)
smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >4kttC (C:)
egtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsr
aavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdqglmfgyatdeteecmpl
tivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvqhdee
vcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpqgdagltgrkiivdtyg
gwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaihplsisifhy
gtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4kttD (D:)
smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >4kttD (D:)
gtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsra
avdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagdq
glmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgav
lpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggp
qgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvl
vqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrta
ayghfgrdsfpwevpkklky

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4kttE (E:)
gshmmpempedmeqeevnipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkf
eqvnlldsnavhhiihdfqphvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaav
gafliyissdyvfdgtnppyreedipaplnlygktkldgekavlennlgaavlripilyg
evekleesavtvmfdkvqfsnksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgt
fhwsgneqmtkyemacaiadafnlpsshlrpitdspvlgaqrprnaqldcskletlgigq
rtpfrigikeslwpflidkrwrqtvfh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kttE (E:)
pnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvnlldsnavhhiihdfq
phvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaavgafliyissdyvfdgtnpp
yreedipaplnlygktkldgekavlennlgaavlripilygevekleesavtvmfdkvqf
snksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgtfhwsgneqmtkyemacaia
dafnlpsshlrpitdspvlqrprnaqldcskletlgigqrtpfrigikeslwpflidkrw
rqtvfh

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4kttF (F:)
gshmmpempedmeqeevnipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkf
eqvnlldsnavhhiihdfqphvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaav
gafliyissdyvfdgtnppyreedipaplnlygktkldgekavlennlgaavlripilyg
evekleesavtvmfdkvqfsnksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgt
fhwsgneqmtkyemacaiadafnlpsshlrpitdspvlgaqrprnaqldcskletlgigq
rtpfrigikeslwpflidkrwrqtvfh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kttF (F:)
vlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvnlldsnavhhiihdfqphvi
vhcaaerrpdvvdasgnlakeaaavgafliyissdyvfdgtnppyreedipaplnlygkt
kldgekavlennavlripilygevekleesavtvmfdkvqfsnksanmdhwqqrfpthvk
dvatvcrqlaekrmldpsikgtfhwsgneqmtkyemacaiadafnlpsshlrpiqrprna
qldcskletlggqrtpfrigikeslwpflidkrwrqtvfh