PDB entry 4ktn

View 4ktn on RCSB PDB site
Description: Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor ((3S)-1-[2-(PYRIDO[2,3-B]PYRAZIN-7-YLSULFANYL)-9H-PYRIMIDO[4,5-B]INDOL-4-YL]PYRROLIDIN-3-AMINE)
Class: Isomerase/isomerase inhibitor
Keywords: cytosol, Nucleotide-binding, Topoisomerase, ATP-binding, DNA girase closed circular double-stranded DNA, Isomerase-Isomerase inhibitor complex
Deposited on 2013-05-20, released 2014-01-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.174
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA gyrase subunit b
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: EF_0005, gyrB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q839Z1 (0-206)
      • expression tag (207-209)
    Domains in SCOPe 2.08: d4ktna1, d4ktna2
  • Heterogens: MJU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ktnA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhaggkfggggykvsgglhgvgssvvnalstsldvrvy
kdgkvyyqeyrrgavvddlkvieetdrhgttvhfipdpeiftettvydfdklatrvrela
flnrglhisiedrregqedkkeyhyeglehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4ktnA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhgvgssvvnalstsldvrvykdgkvyyqeyrrgavvd
dlkvieetdrhgttvhfipdpeiftettvydfdklatrvrelaflnrglhisiedrregq
edkkeyhyegleh