PDB entry 4ksh

View 4ksh on RCSB PDB site
Description: Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)
Class: Isomerase/isomerase inhibitor
Keywords: ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, Isomerase-Isomerase inhibitor complex
Deposited on 2013-05-17, released 2014-01-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.173
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA gyrase subunit b
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: EF_0005, gyrB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q839Z1 (0-206)
      • expression tag (207-209)
    Domains in SCOPe 2.06: d4ksha1, d4ksha2
  • Heterogens: HTT, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4kshA (A:)
    gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
    rgipvgiqaktgrpavetvftvlhaggkfggggykvsgglhgvgssvvnalstsldvrvy
    kdgkvyyqeyrrgavvddlkvieetdrhgttvhfipdpeiftettvydfdklatrvrela
    flnrglhisiedrregqedkkeyhyeglehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kshA (A:)
    gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
    rgipvgiqaktgrpavetvftvlhgvgssvvnalstsldvrvykdgkvyyqeyrrgavvd
    dlkvieetdrhgttvhfipdpeiftettvydfdklatrvrelaflnrglhisiedrregq
    edkkeyhyegleh