PDB entry 4ksg
View 4ksg on RCSB PDB site
Description: Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (4-[(1S,5R,6R)-6-AMINO-1-METHYL-3-AZABICYCLO[3.2.0]HEPT-3-YL]-6-FLUORO-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE)
Class: Isomerase/isomerase inhibitor
Keywords: ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, DNA gyrase negatively supercoils closed circular double-stranded DNA, Isomerase-Isomerase inhibitor complex
Deposited on
2013-05-17, released
2014-01-15
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-12-10, with a file datestamp of
2014-12-05.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.178
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: DNA gyrase subunit b
Species: Enterococcus faecalis [TaxId:226185]
Gene: EF_0005, gyrB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4ksga1, d4ksga2 - Heterogens: 920, TBU, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4ksgA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhaggkfggggykvsgglhgvgssvvnalstsldvrvy
kdgkvyyqeyrrgavvddlkvieetdrhgttvhfipdpeiftettvydfdklatrvrela
flnrglhisiedrregqedkkeyhyeglehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4ksgA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlgssvvnalstsldvrvykdgkvyyqeyrrgavvddlk
vieetdrhgttvhfipdpeiftettvydfdklatrvrelaflnrglhisiedrregqedk
keyhyegleh