SCOPe 2.06: Structural Classification of Proteins

PDB entry 4krm

View 4krm on RCSB PDB site
Description: Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5
Class: transferase/immune system
Keywords: cell surface receptor, glycoprotein, nanobody, VHH domain, Camelid VH domain, antibody, antigen, antibody complex, TRANSFERASE-IMMUNE SYSTEM complex
Deposited on 2013-05-16, released 2013-08-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-08-28, with a file datestamp of 2013-08-23.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: 0.21
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (4-End)
  - expression tag (0-3)
Domains in SCOPe 2.06: d4krma1, d4krma2, d4krma3
Chain 'B':
Compound: Nanobody/VHH domain 7D12
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 4KRM (0-End)
Domains in SCOPe 2.06: d4krmb_
Chain 'C':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (4-End)
  - expression tag (0-3)
Domains in SCOPe 2.06: d4krmc1, d4krmc2, d4krmc3
Chain 'D':
Compound: Nanobody/VHH domain 7D12
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 4KRM (0-End)
Domains in SCOPe 2.06: d4krmd_
Chain 'E':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (4-End)
  - expression tag (0-3)
Domains in SCOPe 2.06: d4krme1, d4krme2, d4krme3
Chain 'F':
Compound: Nanobody/VHH domain 7D12
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 4KRM (0-End)
Domains in SCOPe 2.06: d4krmf_
Chain 'G':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (4-End)
  - expression tag (0-3)
Domains in SCOPe 2.06: d4krmg1, d4krmg2
Chain 'H':
Compound: Nanobody/VHH domain 7D12
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 4KRM (0-End)
Domains in SCOPe 2.06: d4krmh_
Chain 'I':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (4-End)
  - expression tag (0-3)
Domains in SCOPe 2.06: d4krmi1, d4krmi2, d4krmi3
Chain 'J':
Compound: Nanobody/VHH domain 7D12
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 4KRM (0-End)
Domains in SCOPe 2.06: d4krmj_
Chain 'K':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (4-End)
  - expression tag (0-3)
Domains in SCOPe 2.06: d4krmk1, d4krmk2, d4krmk3
Chain 'L':
Compound: Nanobody/VHH domain 7D12
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 4KRM (0-End)
Domains in SCOPe 2.06: d4krml_
Heterogens: NAG, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>4krmA (A:)
leekkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpq
eldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslgl
rslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalc
spegcwgpeprdcvscrnvsrgrecvdkhhhhhh