PDB entry 4kqx

View 4kqx on RCSB PDB site
Description: Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: cofactor switch, Rossmann fold, ketol-acid reductoisomerase, acetohydroxyacid isomeroreductase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2013-05-15, released 2013-06-26
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-07-17, with a file datestamp of 2013-07-12.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.204
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ketol-acid reductoisomerase
    Species: Slackia exigua [TaxId:649764]
    Gene: ilvC, HMPREF0762_00954
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0WGK0
      • engineered mutation (60)
      • engineered mutation (62)
      • engineered mutation (94)
    Domains in SCOPe 2.03: d4kqxa1, d4kqxa2
  • Chain 'B':
    Compound: Ketol-acid reductoisomerase
    Species: Slackia exigua [TaxId:649764]
    Gene: ilvC, HMPREF0762_00954
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0WGK0 (Start-341)
      • engineered mutation (60)
      • engineered mutation (62)
      • engineered mutation (94)
      • expression tag (342-343)
    Domains in SCOPe 2.03: d4kqxb1, d4kqxb2
  • Heterogens: NAD, HIO, MG, HIS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kqxA (A:)
msvktkekemavtilyeqdvdpkviqglkvgiigygsqghahalnlmdsgvdvrvglreg
dsdwktaeeaglkvtdmdtaaeeadvimvlvpdevqpkvyqehiaahlkagntlafahgf
nihygyivppedvnvimcapkgpghivrrqftegsgvpdlacvqqdatgnawdivlsycw
gvggarsgiikatfaeeteedlfgeqavlcgglvelvkagfetlteagyppelayfecyh
emkmivdlmyesgihfmnysisntaeygeyyagpkvineqsreamkeilkriqdgsfaqe
fvddcnnghkrlleqreainthpiettgaqirsmfswikkedlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kqxA (A:)
ilyeqdvdpkviqglkvgiigygsqghahalnlmdsgvdvrvglregdsdwktaeeaglk
vtdmdtaaeeadvimvlvpdevqpkvyqehiaahlkagntlafahgfnihygyivppedv
nvimcapkgpghivrrqftegsgvpdlacvqqdatgnawdivlsycwgvggarsgiikat
faeeteedlfgeqavlcgglvelvkagfetlteagyppelayfecyhemkmivdlmyesg
ihfmnysisntaeygeyyagpkvineqsreamkeilkriqdgsfaqefvddcnnghkrll
eqreainthpiettgaqirsmf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4kqxB (B:)
msvktkekemavtilyeqdvdpkviqglkvgiigygsqghahalnlmdsgvdvrvglreg
dsdwktaeeaglkvtdmdtaaeeadvimvlvpdevqpkvyqehiaahlkagntlafahgf
nihygyivppedvnvimcapkgpghivrrqftegsgvpdlacvqqdatgnawdivlsycw
gvggarsgiikatfaeeteedlfgeqavlcgglvelvkagfetlteagyppelayfecyh
emkmivdlmyesgihfmnysisntaeygeyyagpkvineqsreamkeilkriqdgsfaqe
fvddcnnghkrlleqreainthpiettgaqirsmfswikkedlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kqxB (B:)
mavtilyeqdvdpkviqglkvgiigygsqghahalnlmdsgvdvrvglregdsdwktaee
aglkvtdmdtaaeeadvimvlvpdevqpkvyqehiaahlkagntlafahgfnihygyivp
pedvnvimcapkgpghivrrqftegsgvpdlacvqqdatgnawdivlsycwgvggarsgi
ikatfaeeteedlfgeqavlcgglvelvkagfetlteagyppelayfecyhemkmivdlm
yesgihfmnysisntaeygeyyagpkvineqsreamkeilkriqdgsfaqefvddcnngh
krlleqreainthpiettgaqirsmfswikkedle