PDB entry 4kq5
View 4kq5 on RCSB PDB site
Description: Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate
Class: Transferase
Keywords: Isoprene biosynthesis, Lipid synthesis, steroid biosynthesis, Transferase, dimethylallyl pyrophosphate, Isoprenoid Pathway, Cholesterol Synthesis, Bisphosphonates
Deposited on
2013-05-14, released
2014-04-30
The last revision prior to the SCOPe 2.06 freeze date was dated
2014-04-30, with a file datestamp of
2014-04-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.188
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: farnesyl pyrophosphate synthase
Species: Homo sapiens [TaxId:9606]
Gene: FDPS, FPS, KIAA1293
Database cross-references and differences (RAF-indexed):
- Uniprot P14324
- engineered mutation (225)
Domains in SCOPe 2.06: d4kq5a_ - Heterogens: MG, ZOL, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4kq5A (A:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafasfylpiaaamymag
idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk
Sequence, based on observed residues (ATOM records): (download)
>4kq5A (A:)
vyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvvaf
relveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvglda
indanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrf
tekryksivkyktafasfylpiaaamymagidgekehanakkillemgeffqiqddyldl
fgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeel
dlpavflqyeedsyshimalieqyaaplppavflglarkiyk