PDB entry 4kpw

View 4kpw on RCSB PDB site
Description: Crystal structure of His-tagged human thymidylate synthase R175A mutant
Class: transferase
Keywords: interface hot spot, Transferase, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
Deposited on 2013-05-14, released 2014-05-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (186)
    Domains in SCOPe 2.08: d4kpwa_
  • Heterogens: SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kpwA (A:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddariimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >4kpwA (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvid
tiktnpddariimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfn
iasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkve
kiddfkaedfqiegynphptikmem