PDB entry 4klz
View 4klz on RCSB PDB site
Description: Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
Class: protein binding
Keywords: small GTPase, molecular switch (GTPase), GDP/GTP binding, PROTEIN BINDING, GUANINE NUCLEOTIDE BINDING
Deposited on
2013-05-07, released
2014-09-17
The last revision prior to the SCOPe 2.05 freeze date was dated
2014-09-17, with a file datestamp of
2014-09-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.198
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTP-binding protein Rit1
Species: Homo sapiens [TaxId:9606]
Gene: RIT1, RIBB, RIT, ROC1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d4klza_ - Heterogens: GDP, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4klzA (A:)
gssreyklvmlgaggvgksamtmqfishrfpedhdptiedaykiririddepanldildt
agqaeftamrdqymragegfiicysitdrrsfhevrefkqliyrvrrtddtpvvlvgnks
dlkqlrqvtkeeglalarefscpffetsaayryyiddvfhalvreirrkekea
Sequence, based on observed residues (ATOM records): (download)
>4klzA (A:)
eyklvmlgaggvgksamtmqfishrfpedhdptiedaykiririddepanldildtagqy
mragegfiicysitdrrsfhevrefkqliyrvrrtddtpvvlvgnksdlkqlrqvtkeeg
lalarefscpffetsaayryyiddvfhalvreirrk